| Preliminary Program subject to change |
| TI016 Continuous Processing with Process Analytical Technology |
| Continuous processing has long been well established in various industries including the food, dairy, and chemical industry because large-volume productions are often found in these industries. Despite the many advantages of continuous processing as compared with batch processing such as low operating and capital costs, consistent quality, ease of automation, reduced scale-up and streamlined process development, batch processing has been traditionally used in industries where low-volume, sophisticated products demanding stringent quality attributes are manufactured (e.g. pharmaceutical industry). With the advances in process analytical technology, which is adopted in the pharmaceutical industry as part of the PAT initiative, in equipment design and automation, as well as in process modeling and control, continuous processing is becoming a feasible option even for the manufacture of relatively low-volume products.
Papers that enhance our understanding of continuous particulate processes such as blending, granulation, spray drying, milling, roller compaction, etc. are invited from both academia and all sectors of industry. They can be experimental, theoretical, and/or computational. Although pharmaceutical applications will be given special consideration, the session is intended to serve as a venue for sharing fundamental, continuous particulate processing knowledge across a multitude of industries. Those papers that consider process analytical technology and/or modeling tools toward characterizing continuous processes or controlling them are especially welcome. |
| Topical I: Pharmaceutical Engineering for the 21^st Century (TI) |
| Particle Production and Characterization (03a), Pharmaceuticals (15b) |
Chair
Ecevit Bilgili
Senior Research Chemical Engineer
Global Pharmaceutical Commercialization, Merck Manufacturing Division
Merck & Co., Inc.
WP 78-110, P.O. Box 4
West Point, PA 19486
Phone Number: 215-652-9824
Fax Number: 215-652-2821
Email: ecevit_bilgili@merck.com
CoChair
Mark Bumiller
Vice President of Business Development
Malvern Instruments
10 Southville Road
Southboro, MA 01772
Phone Number: 508-480-0200 ext. 222
Fax Number: 508-460-9692
Email: Mark.Bumiller@malvernusa.com
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| Welcoming Remarks |
Continuous Powder Blending For Pharmaceutical Applications
Michael Gentzler, Ecevit Bilgili, Brit L. Rudeen, Mano Ramasamy and Steve J. Heidel, Merck & Co., Inc., PO Box 4, West Point, PA 19486 |
Model Predictive Control on Roller Compaction for Pharmaceutical Manufacturing
Shuo-Huan Hsu1, Girish Joglekar1, Gintaras V. Reklaitis2 and Venkat Venkatasubramanian2, (1)Discovery Park, Purdue University, West Lafayette, IN 47907, (2)School of Chemical Engineering, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN 47907 |
Experimental Study And Computational Modeling Of Continuous Powder Mixing Processes
Patricia M. Portillo, Marianthi G. Ierapetritou and Fernando J. Muzzio, Rutgers University, Chemical and Biochemical Engineering, 98 Brett Road, Piscataway, NJ 08854 |
Determination Of Granulation Growth Rates: An Evaluation Between Fbrm And Sieve Analysis
Kevin Macias and M. Teresa Carvajal, Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907 |
| Break |
Effect of Stirrer Design on the Homogeneity of a Pharmaceutical Powder Mixture
Henri Berthiaux1, Cendrine Gatumel2 and Jean-Louis Dirion2, (1)Research centre RAPSODEE - UMR CNRS 2392, Ecole des Mines d'Albi Carmaux, Campus Jarlard, route de Teillet, ALBI, 81 000, France, (2)Research Centre RAPSODEE, Ecole des Mines d'Albi Carmaux, Campus Jarlard, route de Teillet, ALBI, 81 000, France |
Application Of In-Line Transmission Nir For Improved Process Understanding And Control Of A Continuous Mixing Process
Gregory M. Troup1, John P. Higgins1, Craig A. Mckelvey2, Michael Lowinger2, Jeff S. Ko3, Luke R. Schenck3, Robert F. Meyer3 and Brit L. Rudeen3, (1)Process Analytics, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, (2)Materials Characterization & Technology Assessment, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486, (3)Pharmaceutical Commercialization Technology, Merck & Co. Inc., 770 Sumneytown Pike, West Point, PA 19486 |
Continuous Dry Powder Blending: Effect of Process Variables and Material Properties
Lakshman Pernenkil1, Farzad J. Yazdi1, Jason Whittaker1 and Charles Cooney2, (1)Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 56-454, CAMBRIDGE, MA 02139, (2)Department of Chemical Engineering, Massachusetts Institute of Technology, Room 56-469, 77 Massachusetts Avenue,, Cambridge, MA 02139 |
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