Preliminary Program subject to change
TA004 Synthetic Systems Biology
OverviewSystems biology is the study of whole biological ensembles, rather than isolated parts, in order to build a predictive biological understanding of a defined system’s behavior. Synthetic biology has been defined as the design and construction of systems that exhibit complex dynamical or logical behavior. The intersection between these two fields is likely to significantly enhance efforts in design-based biological engineering and therefore greatly increase human capability. This session will cover current applications of systems biology theory and techniques to aid in the design of synthetic biological systems. In addition, efforts that apply synthetic biology research as new tools to expand systems-level understanding or as new concepts in systems biology are of interest.
Primary SponsorTopical A: Systems Biology (TA)

Chair

Christina Smolke
Assistant Professor
Chemistry and Chemical Engineering
California Institute of Technology
236A Spalding
Mail Code 210-41
Pasadena, CA 91125
Phone Number: (626) 395-2460
Fax Number: (626) 568-8743
Email: smolke@cheme.caltech.edu

CoChair

Kristala Prather
Assistant Professor
Chemical Engineering
MIT
77 Massachusetts Ave
Cambridge, MA 02139
Phone Number: 617.253.1950
Email: kljp@mit.edu
Combinatorial Biosynthesis Of Targeted Tetracycline Polyketides Through Protein Engineering
Wenjun Zhang, Chemical and Biomolecular Engineering, University of California at Los Angeles, 420 Westwood Plaza, 5667 Boelter Hall, Los angeles, CA 90095 and Yi Tang, Chemical and Biomolecular Engineering, University of California at Los Angeles, 420 Westwood Plaza, 5667 Boelter Hall, Los Angeles, CA 90095
Single-Cell Zeroth-Order Ssra Protein Degradation Kinetics Enhances the Robustness of Synthetic Gene-Metabolic Oscillator
Wilson W. Wong, Chemical Engineering, UCLA, 5531 Boelter Hall, Los Angeles, CA 90095, Tony Tsai, Biomathematics, UCLA, 5531 Boelter Hall, Los Angeles, CA 90095 and James C. Liao, UCLA, 5531 Boelter Hall, Los Angeles, CA 90095
Towards Microbial Synthesis Of Glucaric Acid
Tae Seok Moon1, Leah Octavio2 and Kristala Jones Prather1, (1)Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 66-425, Cambridge, MA 02139, (2)Computational and Systems Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 66-425, Cambridge, MA 02139
Tat-Regulated Promoter Occupancy Mediates Open Loop Stochastic Bimodality In HIV1 Gene Expression And Latency
John C. Burnett1, Ron Skupsky2, Adam P. Arkin3 and David V. Schaffer1, (1)Chemical Engineering, University of California at Berkeley, Department of Chemical Engineering, 201 Gilman Hall, Berkeley, CA 94720-1462, (2)California Institute for Quantitative Biomedical Research, University of California at Berkeley, Berkeley, CA 94720, (3)Bioengineering, University of California at Berkeley, Berkeley, CA 94720-1462
Break
Towards Programming Network Connectivities: Ligand-Regulated Shrna Switches
Chase L. Beisel, Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 and Christina Smolke, Chemistry and Chemical Engineering, California Institute of Technology, 236A Spalding, Mail Code 210-41, Pasadena, CA 91125
Fabrication Of Anti-Obesity Stilbene Analogues Using Engineered Microbial Platforms: Structure-Function Properties Towards Inhibition Of Digestive Enzymes
Effendi Leonard1, Chin Giaw Lim2, Zacchary Fowler2, Kok Hong Lim2 and Mattheos Koffas2, (1)Chemical Engineering, Massachusetts Institute of Technology (MIT), 77 Massachusetts Ave, Cambridge, MA 02139, (2)Chemical and Biological Engineering, State University of New York, 303 Furnas Hall, Buffalo, NY 14260
Engineering The Salmonella Type Three Secretion System For Heterologous Protein Production
Danielle Tullman-Ercek1, Daniel Widmaier1, Ethan Mirsky1, Karsten Temme2 and Christopher Voigt1, (1)Pharmaceutical Chemistry, University of California - San Francisco, 1700 4th St., Byer's Hall Rm 409, MC 2540, San Francisco, CA 94158, (2)Bioengineering, University of California - San Francisco, 1700 4th St., Byer's Hall Rm 409, MC 2540, San Francisco, CA 94158

Topical A: Systems Biology