Metal oxide nanostructured particles, because of their high surface area and unique morphology, have been shown to be effective in inactivating a wide variety of chemical warfare agents, biological agents, and toxic industrial chemicals, and in detoxification of indoor spaces. Such applications may require aerosolization of these metal oxide nanomaterials into the affected space to scavenge unwanted particles or gaseous contaminants. To be effective, the particles must be deployed with the desired particle size distribution, concentration, and sufficient coverage distribution over the affected space. This research was conducted to characterize two types of metal oxide nanostructured particles, which differed in terms of the specific surface area and the size of the primary particle. Each of the metal oxide materials was aerosolized into an enclosed chamber (2.4 m x 2.4 m x 3.6 m) using a pressurized canister. The size distribution and number concentration of the particles inside the chamber were monitored with a Scanning Mobility Particle Sizer (SMPS) spectrometer and an Aerodynamic Particle Sizer (APS) spectrometer. The Tapered Element Oscillating Microbalance (TEOM) is also used for real time total mass concentration. The particles were compared in terms of size distribution and mass concentration. The effect of canister pressure (40 psig vs. 80 psig) was also considered. Results showed that the two nanostructured materials differed in terms of the evolution of the size distribution and decay in concentration. Additionally, canister pressure seemed to affect the size distribution of the aerosolized particles.