In packed beds at low Reynolds numbers, flow maldistribution can adversely affect the chemical conversion rates due to the fluid's tendency to preferentially flow through open regions of the bed. These effects can be minimized by increasing the voidage and allow uniform flow distribution. High voidages and uniform flow distribution are possible by using Microfibrous entrapped sorbents (MFES). MFES consists of small particles (100-200 µm) of adsorbent entrapped in sintered bonded micro-fibers (2-10 µm). These materials have been developed by Auburn's Center for Microfibrous Materials Manufacturing (CM3) using a simple wet-layup process. These materials showed improvement in chemical conversion rates over packed beds. Computational Fluid Dynamics (CFD) is being used to understand the physical and chemical phenomena involved in the enhancement of chemical conversion rates. In this study, particles are uniformly clustered in all directions in the material to analyze the effects of flow maldistribution. Clustering of particles is varied by using a dimensionless parameter called clustering parameter which goes from 0 (uniformly distributed particles) to 1 (highly clustered particles). The effect of flow maldistribution on chemical conversion is studied by varying the dimensionless numbers which characterize different gas-phase reactions: viscosity, diffusivity, and reaction rates. The dimensionless numbers that are varied in this study are Reynolds number, Peclet number, and Damkohler number.