Wednesday, November 7, 2007: 8:30 AM-11:00 AM
Grand Ballroom I (Salt Palace Convention Center)

Topical A: Systems Biology (TA)

#383 - Synthetic Systems Biology (TA004)
Systems biology is the study of whole biological ensembles, rather than isolated parts, in order to build a predictive biological understanding of a defined system’s behavior. Synthetic biology has been defined as the design and construction of systems that exhibit complex dynamical or logical behavior. The intersection between these two fields is likely to significantly enhance efforts in design-based biological engineering and therefore greatly increase human capability. This session will cover current applications of systems biology theory and techniques to aid in the design of synthetic biological systems. In addition, efforts that apply synthetic biology research as new tools to expand systems-level understanding or as new concepts in systems biology are of interest.
Chair:Christina Smolke
CoChair:Kristala Prather
8:30 AM383aCombinatorial Biosynthesis Of Targeted Tetracycline Polyketides Through Protein Engineering
Wenjun Zhang, Yi Tang
8:50 AM383bSingle-Cell Zeroth-Order Ssra Protein Degradation Kinetics Enhances the Robustness of Synthetic Gene-Metabolic Oscillator
Wilson W. Wong, Tony Tsai, James C. Liao
9:10 AM383cTowards Microbial Synthesis Of Glucaric Acid
Tae Seok Moon, Leah Octavio, Kristala Jones Prather
9:30 AM383dTat-Regulated Promoter Occupancy Mediates Open Loop Stochastic Bimodality In HIV1 Gene Expression And Latency
John C. Burnett, Ron Skupsky, Adam P. Arkin, David V. Schaffer
9:50 AM Break
10:00 AM383eTowards Programming Network Connectivities: Ligand-Regulated Shrna Switches
Chase L. Beisel, Christina Smolke
10:20 AM383fFabrication Of Anti-Obesity Stilbene Analogues Using Engineered Microbial Platforms: Structure-Function Properties Towards Inhibition Of Digestive Enzymes
Effendi Leonard, Chin Giaw Lim, Zacchary Fowler, Kok Hong Lim, Mattheos Koffas
10:40 AM383gEngineering The Salmonella Type Three Secretion System For Heterologous Protein Production
Danielle Tullman-Ercek, Daniel Widmaier, Ethan Mirsky, Karsten Temme, Christopher Voigt

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