Biodegradable Hydrogel Systems as Orthopedic Implants for Growth Plate Regeneration

Biodegradable hydrogel systems are some of the most promising biomaterials for controlled drug delivery, and often medical implants. In this research the synthesis and characterization of biodegradable hydrogels has been completed for a target application as orthopedic implants in patients suffering from growth plate injuries. Specifically tailored poly(beta-amino ester) biodegradable hydrogel systems have been developed which possess a given set of properties including appropriate degradation profiles, mechanical properties, porous structures created using various methods, and biocompatibility. Initial work included the synthesis and characterization of the macromer precursors. Macromers were characterized using gel permeation chromatography (GPC). Then, the macromer conversion to hydrogel was observed using FTIR analysis. Other characterization that was completed included mechanical properties through compressive analysis, pore characterization through scanning electron microscopy (SEM) imaging, and biocompatibility of systems through cell toxicity studies.