This session focuses on the development and application of metabolic engineering techniques and principles to mammalian systems, in the context of physiology and disease pathophysiology. Relevant topics include: (1) the characterization of pathway flux distributions in metabolic derangements of disease, such as diabetes, cancer, and hypercatabolic syndromes, etc.; (2) the development of nutritional, pharmacological, and other interventions to ameliorate these conditions; (3) the development of techniques to quantify fluxes in vivo, for example using mass balances, radiolabels, stable isotopes, etc.; (4) the development of techniques to elucidate the regulation of metabolic pathway networks using metabolomic, proteomic, and genomic information.

Engineering Fundamentals in Life Science