Thermodynamics of Protein Folding and Aggregation

Monday, November 17, 2008: 12:30 PM
303-A (Pennsylvania Convention Center)

Description:
This session seeks submissions focused on experimental and theoretical characterization and prediction of the thermodynamics and mechanism(s) of protein folding, and the role of aggregation as an on- or off-pathway aspect of (un)folding. Aggregation in this context is intended to include both reversible association and net irreversible aggregate formation. Preference will be given to presentations that provide insights of general utility, and those focused on relatively complex (un)folding pathways such as multi-domain and natively multimeric proteins.


Sponsor:
Bioengineering


Chair:
Todd M. Przybycien
Email: todd@andrew.cmu.edu

CoChair:
John A. Morgan
Email: jamorgan@purdue.edu


12:30 PM
(126a) Early Steps In Aggregation of Amyloidogenic Peptide Gnnqqny
Allam S. Reddy, Manan Chopra and Juan J. De Pablo

12:50 PM
(126b) New Twists to the Amyloid Folding Problem Revealed by Solid State NMR and Electron Microscopy of Alzheimer's Beta Amyloid Fibrils
Anant K. Paravastu, Isam Qahwash, Wa-Ming Yao, Richard D. Leapman, Steven C. Meredith and Robert Tycko

1:10 PM
(126c) Elucidating Therapeutic Monoclonal Antibody Aggregation
Veysel Kayser, Vladimir Voynov, Naresh Chennamsetty, Bernhard Helk, Kurt Forrer and Bernhardt L. Trout

1:30 PM
(126d) Air/water Interface Induced Folding and Self-Assembly of Amyloid-Beta Peptide Seed Fibrillogenesis
Eva Y. Chi, Amy Winans, Shelli L Frey, Jaroslaw Majewski, Kristian Kjaer and Ka Yee C Lee

1:50 PM

2:20 PM
(126f) Effect of Fermentation Conditions on Inclusion Body Quality in High Cell Density E. Coli Fermentations
Rishard H. Chen, Clarissa S. Lui, Matthew P. DeLisa, Gerd Ritter, Lloyd J. Old, Carl Batt and Michael L. Shuler

2:40 PM
(126g) Time Dependent Saxs Analysis of Insulin Oligomerization
Mirco Sorci, Joel E. Morgan, Kurt Erlacher and Georges Belfort
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division