Session: Batch to Continuous Pharmaceutical Processing Challenges (2008 Annual Meeting)

Monday, November 17, 2008: 3:15 PM

Room 204-C (Pennsylvania Convention Center)

Description:

For most companies in the pharmaceutical industry, converting a batch API process into continuous process is likely to go beyond being a technical challenge to the development chemists and engineers. Supporting groups in regulatory, EHS and Quality roles will also be impacted. In this session we want to identify and explore the big challenges facing the development of continuous processes and the conversion of batch to continuous processes.

Sponsor:

Topical 5: Green Engineering and Sustainability in the Pharmaceutical Industry

Co-Sponsor(s):

Pharmaceuticals (15b)

Chair:

Daniel R. Pilipauskas
Email: daniel.r.pilipauskas@pfizer.com

CoChair:

Fernando J. Muzzio
Email: muzzio@soemail.rutgers.edu

3:15 PM

Introductory Remarks

3:25 PM

(134a) Continuous Processing in Pharmaceutical Process Development
Chenchi Wang and Thomas LaPorte

3:45 PM

(134b) Development of Continuous Flow Processes for Pharmaceutical Manufacturing
Jerry S. Salan

4:05 PM

(134c) Assessing the Effectiveness of a Spinning Tube-In-Tube Reactor
James Ciszewski and Michael Gonzalez

4:25 PM

(134d) Removing Palladium from Reaction Mixtures by Fixed Bed Adsorption
Brian G. Lefebvre, Caitlin A. Boyd, Sonia M. Berberena, Laura E. Kuczynski, Pamela L. Kubinski, Megerle L. Scherholz, Dr. Stephanie Farrell, Robert P. Hesketh and Michael J. Girgis

4:45 PM

(134e) Separation of Fine Chemical Species by Means of Continuous Chromatography: The Simulated Moving Bed Technology
Pedro Sá Gomes, Michal Zabka, Viviana Silva and Alírio E. Rodrigues

5:05 PM

(134f) Possibility of Separating Enantiomeric Compounds Continuously with Supercritical CO2 and Chiral Ionic Liquids
Hiroshi Machida, Wataru Endo, Ryosuke Taguchi, Masaru Watanabe, Yoshiyuki Sato and Richard L. Smith

5:25 PM

(134g) Effects of Rotation Rate, Mixing Angle, and Cohesion In Two Continuous Powder Mixers – a Statistical Approach
Patricia M. Portillo, Aditya U. Vanarase, M.G. Ierapetritou and Fernando J. Muzzio

See more of this Group/Topical: Topical 5: Green Engineering and Sustainability in the Pharmaceutical Industry

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