Start | Grid View | Browse by Day OR Group/Topical | Author Index |

Applications of Chemometrics for Process Development

Wednesday, November 19, 2008: 3:15 PM
Washington A Room (Loews Philadelphia Hotel)

Description:
Innovations in Process Development are empowered by using Chemometrics techniques to derive useful information from complex data systems. A wide range of chemometrics applications is encompassed in this session, including increased process understanding through optimization of experimental parameters, design of experiments, calibration, signal processing and enhancement of PAT development.


Sponsor:
Process Research and Innovation


Chair:
James Marek
Email: james.marek@abbott.com

CoChair:
Jean W. Tom
Email: jean.tom@bms.com


3:15 PM
Welcoming Remarks

3:20 PM
(521a) Introduction to Chemometrics -- Design of Experiments and Principal Component Analysis
Dongsheng Bu and Andrew Chu

3:45 PM
(521b) Data Exploration Analysis In Process Development: Application to API Characterization
Jose E. Tabora, Jessica Defreese, Prashant Deshpande and Jean Tom

4:10 PM
(521c) Scale-up a Complex Pharmaceutical Batch Process Using Mid-IR: The Role of Simple Peak Height Profiling, Partial Least Squares (PLS) Modeling and Dynamic Principal Component Analysis (PCA)
Shan Lin, James Marek and Samrat Mukherjee

4:35 PM
(521d) Application of Chemometrics in Process Monitoring of Synthesizing Preferred Isomer
Dongsheng Bu and Andrew Chu

5:00 PM
(521e) Utilization of Single Crystal X-Ray Studies of Process Relevant Pharmaceutical Crystal Forms to Support Qbd
John D. DiMarco, Michael A. Galella, Raymond P. Scaringe, Carolyn J. Pommier and Jack Z. Gougoutas
See more of this Group/Topical: Process Development Division
<< Previous Session | Next Session >>