Abstract: Design of Microfluidic Platforms to Screen for Crystallization Conditions (2009 Annual Meeting)

Thursday, November 12, 2009: 9:44 AM

Hermitage A (Gaylord Opryland Hotel)

Michael R. Thorson, Department of Chemical & Biomolecular Engineering, University of Illinois at Urbana Champaign, Urbana, IL

Benjamin R. Schudel, Department of Chemical & Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL

Yuchuan Gong, Solid State Sciences, Abbott Laboratories, North Chicago, IL

Geoff G.Z. Gong, Solid State Sciences, Abbott Laboratories, North Chicago, IL

Charles F. Zukoski, Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana Champaign, Urbana, IL

Paul J.A. Kenis, Department of Chemical & Biomolecular Engineering, University of Illinois at Urbana Champaign, Urbana, IL

Efficient screens for crystal formation and polymorph identification are an expensive and critical step in active pharmaceutical ingredient (API) development. In this talk we will discuss our efforts to develop microfluidic platforms capable of screening for suitable crystal forms and conditions of potential APIs. These microfluidic platforms utilize much smaller amounts of API per condition screened than the present well-plate based crystallization screening methods.

Additional text will be provided pending approval from Abbott Laboratories.

Extended Abstract: File Not Uploaded

See more of this Session: Advances and Case Studies in Crystallization and Post-Crystallization Processing
See more of this Group/Topical: Separations Division