This preliminary program is subject to change.

Solid Form Selection: Cocrystals, Salts, Solvates, and Polymorphs


Description:
Continuous improvement of the physicochemical properties of active pharmaceutical ingredients (APIs) such as solubility, bioavailability, dissolution rate, stability, hygroscopicity, crystallinity and taste, represents an emerging area of research and development. This session focuses on the selection of solid forms including cocrystals, salts, solvates and polymorphs in crystallization processes, as well as the screening, predicting, manipulating and controlling techniques for such product selection.

Sponsor:
Crystallization and Evaporation


Chair:
Guangwen He
Institute of Chemical & Engineering Sciences
1 Pesek Road, Jurong Island
Singapore Phone Number: (65) 67963779
Email: he_guangwen@ices.a-star.edu.sg

Co-Chair:
Jan Sefcik

Papers:
Polymorph Control of Nanosized Organic Molecular Crystals On the Engineered Surfaces
Kitae Kim, Illinois Institute of Technology; Insung Lee, Illinois Institute of Technology; Andrea Centrone, Massachusetts Institute of Technology; Allan Myerson, Illinois Institute of Technology
Accurate Lattice Energy Minimization of Cocrystals, Salts and Solvates Containing Flexible Molecules
Andrei V. Kazantsev, Imperial College London; Panos G. Karamertzanis, Imperial College London; Claire S. Adjiman, Imperial College London; Constantinos C. Pantelides, Process Systems Enterprise Ltd.
Predicting Multicomponent Crystal Formation: The Interplay Between Homomeric and Heteromeric Interactions
Guangwen He, Institute of Chemical & Engineering Sciences; Pui Shan Chow, Institute of Chemical & Engineering Sciences; Reginald B. H. Tan, Institute of Chemical & Engineering Sciences
Alcohol Solvates of Sodium Naproxen
Krystle J. Chavez, Georgia Institute of Technology; Ronald W. Rousseau, Georgia Institute of Technology
Challenges in the Solid State Characterization of a Non-Conventional Pharmaceutical Hydrate
Maria C. Sandoval, Bristol-Myers Squibb Company; Roxana Schlam, Bristol-Myers Squibb Company; George Crull, Bristol-Myers Squibb Company; Qi Gao, Bristol-Myers Squibb Company; Albert DelMonte, Bristol-Myers Squibb Company
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