This preliminary program is subject to change.

Advances in Small Scale Predictive Abilities


Description:
We invite presentations on projects where small scale results were translated to pilot or manufacturing scale (scale-up) or vice versa (scale-down). Of most interest are projects i) with a large difference in scale (e.g. volume scale factor of 1000 or more), or where the laboratory scale was smaller than standard practice and ii) where the basis of successful scaling is understood and will be presented (e.g. in the form of dimensionless groups, or other models). We also welcome presentations where lab scale equipment was characterized experimentally (e.g. with respect to mixing, heat transfer) in order to then design appropriate experiments for successful scale-up.

Sponsor:
Pharmaceuticals


Chair:
Joe Hannon
DynoChem Inc
Wilmington, DE 19803
Phone Number: 412-343-7523
Email: joe.hannon@scale-up.com

Co-Chair:
Hector Guzman

Papers:
Scale-up and Scale-Down of Heat Flow Data
Jeffry K. Niemeier, Eli Lilly and Co.
Velocity Distribution and Shear Rate Variability Resulting From Changes in the Agitation Speed in the USP Dissolution Testing Apparatus II
Yimin Wang, New Jersey Institute of Technology; Ge Bai, New Jersey Institute of Technology; Piero M. Armenante, New Jersey Institute of Technology
Effect of Scale up On Compaction Properties of High Drug Load Granulation Prepared by Foam Technology
Admassu Abebe, Bristol-Myers Squibb; Niranjan Kottala, Bristol-Myers Squibb Comany; Ganeshkumar A. Subramanian, Bristol Myers Squibb; Robert Jerzewski, Bristol Myers Squibb
Estimation of Powder Blend Particle Size Distribution and Flow Properties From Single Components
Matthew P. Mullarney, Pfizer Inc.; Jonathan I. Hiller, Pfizer Inc.; Beth A. Langdon, Pfizer Inc.; Weili Yu, Pfizer Inc.
Prediction of Density From the Uniaxial and Roller Compaction of Viscoelastic Pharmaceutical Powder Mixtures
Anna Rose Alsman-Hayes, Purdue University; Dhananjay A. Pai, Purdue University; Martin R. Okos, Purdue University; Osvaldo Campanella, Purdue University
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division