Session: Downstream Processing: Purification/Polishing (2009 Annual Meeting)

Description:

This session will focus on highlighting the latest advances in downstream processing relevant to purification/polishing operations including rapid process development, improved efficiency, cost reduction, integration of operations and handling of high titre streams. Topics to be covered include, but are not limited to: Uni- and multi-modal chromatography, membrane-based separations and filtration, extraction, precipitation and crystallization.

Sponsor:

Bioengineering

Co-Sponsor(s):

Pharmaceuticals (15b)

Chair:

Bruno F. Marques
Investigator
GlaxoSmithKline
Biopharmaceutical Development
709 Swedeland Road
King of Prussia, PA 19406
Phone Number: 610-270-7024
Fax Number: 610-270-7449
Email: bruno.marques@gsk.com

Co-Chair:

Todd M. Przybycien

Papers:

556a

Knockout and Mutational Tailoring of Host Strains to Simplify Bioseparation
Patrick Bartlow, University of Pittsburgh; Ryan Haley, University of Arkansas; Mohammad Ataai, University of Pittsburgh; Robert R. Beitle, University of Arkansas

556b

Application of ATPS Strategies for the Potential Recovery of Recombinant Proteins From of Alfalfa Extracts
Celeste C. Ibarra-Herrera, Tecnologico de Monterrey; Oscar Aguilar, Tecnologico de Monterrey; Marco Rito-Palomares*, Tecnologico de Monterrey

556c

Non-Chromatographic Antibody Purification Using Aqueous Two-Phase Systems
Lisong N. Mao, Biogen IDEC; Matthew Westoby, Biogen IDEC; Andy Koswara, Biogen IDEC; Jameson Rogers, Biogen IDEC; John Pieracci, Biogen IDEC; Lynn Conley, Biogen IDEC; Jörg Thömmes, Biogen IDEC

556d

Optimization of ELP-Intein Mediated Protein Purification by Salt Substitution
Baley A. Fong, Princeton University; Wan-Yi Wu, Princeton University; David W. Wood, Princeton University

Break

556e

Evaluation and Prediction of Protein Binding to Multi-Modal Anion Exchange Chromatographic Systems
Ying Hou, Rensselaer Polytechnic Institute; Steven M. Cramer, Rensselaer Polytechnic Institute

556f

Comparison of An Existing Scale-Down Membrane Adsorber Device to Ultra Small Membrane Adsorbers for Rapid Screening and Process Development
Brian Kluck, Genentech, Inc; Tim Tully, Genentech, Inc; Amit Mehta, Genentech, Inc; Wolfgang Demmer, Sartorius Stedim Biotech GmbH; Rene Faber, Sartorius Stedim Biotech GmbH; Nathalie Fraud, Sartorius Stedim North America

556g

Knowledge-Driven Development: An Efficient Experimental Sequence for Refold Optimization
Sydney D. Hoeltzli, Pfizer; John J Buckley, Pfizer; Robert Gallavan, Pfizer (retired); Gary V Johnson, Pfizer

See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division

<< Previous Session | Next Session >>