Charge Reversal Liposomes for Cancer Nuclear Drug Delivery

Cationic liposomes have fast cellular uptakes but nonspecific cellular uptakes and are toxic, immediately clear out from the blood, accumulate in lung, Herein, we report liposomes that can undergo negative-to-positive charge-reversal triggered by the solid tumor extracellular- or lysosomal (4-5) acidity for nuclear drug delivery. Doxorubicin loaded in the liposomes is more cytotoxic to tumor cells than the free drug. The liposomes have a long blood circulation time and thus are good for in vivo cancer drug delivery.