Session: Integrated API and Drug Product Development (2010 Annual Meeting)

Description:

This session will focus on the interaction between active pharmaceutical ingredient (API) properties and the properties of the final product required to achieve pharmaceutical benefit. We invite submissions on topics including but not limited to: API - excipient interactions, enhancement of API solubility, API surface, morphology or particle size effects, impact of API variability on its delivery, extended release delivery systems, processing strategies for property optimization.

Sponsor:

Pharmaceuticals

Chair:

Marylee Z. Southard
University of Kansas
Chemical & Petroleum Engrg. Dept.
1530 W. 15th Street, Room 4132
Lawrence, KS 66045
Phone Number: 785-864-3868
Fax Number: 785-864-4967
Email: marylee@ku.edu

Co-Chair:

Hector Guzman
Process Engineering
Alkermes
Cambridge, MA 02421
Phone Number: 781-674-7882
Fax Number: 781-863-8914
Email: hector.guzman@alkermes.com

Papers:

30a

Towards a Better Understanding of Amorphous Solids and Supercooled Liquids and Their Stability During Pharmaceutical Development
Yanfeng Zhang, Merck Research Laboratories; Shu Li, Columbia University (currently at Nalco); Yaling Wang, Merck Research Laboratories; Annette Bak, Merck Research Laboratories

30b

Solvate Devolatilization Via Hot Melt Extrusion
Michael B. Eglesia, Merck & Co.; Luke Schenck, Merck & Co.; Yun Shao Feng, Merck & Co.; Robert F. Meyer, Merck & Co.

30c

Evaluation of the Ability of Different Polymers to Inhibit Drug Crystallization Upon Rapid Solvent Evaporation – Development of a Small Scale Screening Method
Bernard Van Eerdenbrugh, Purdue University; Lynne S. Taylor, Purdue University

30d

Micron-Sized Drug Release Rate Control From Strip Film Matrix as An Alternative API Carrier
Bo Zhou, Purdue University; M. Teresa Carvajal, Purdue University; Amanda Goh, Purdue University; Mikhail Slipchenk, Department of Biomedical Engineering; Ji-Xin Cheng, Purdue University; David Nivens, Purdue University; Rodolfo Pinal, Purdue University

30f

Crystal Habit Modification to Improve Powder Flowability, a Case Study
Lotfi Derdour, Bristol-Myers Squibb Co; Dimitri Skliar, Bristol-Myers Squibb Co; Daniel Hallow, Bristol-Myers Squibb Co; Jun Li, Bristol-Myers Squibb Co; Michael Randazzo, Bristol-Myers Squibb Co; Frederic Buono, Bristol-Myers Squibb Co

See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division

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