This preliminary program is subject to change.

Reaction Engineering in API Synthesis


Description:
Reaction engineering work in the development of API synthesis may include kinetic modeling, reactor design, and the integration of process analytical technologies. Applications involving multiphase systems, mass transfer limited operations, and novel reactor design on observed kinetic behavior is of particular interest to this session. Case studies that provide a better understanding of kinetics gained through process development are also encouraged to be submitted.

Sponsor:
Pharmaceuticals


Chair:
David J. am Ende
Research Fellow
Pfizer, Inc
Chemical R&D, MS 8118N-202, Bldg 118E room 303L
Eastern Point Road
Groton, CT 06340
Phone Number: 860-441-6504
Email: david.j.amende@pfizer.com

Co-Chair:
Adam S. Butterbaugh
Assoc. Consultant Engineer
Eli Lilly & Co.
Chemical Process R&D
DC 4813
Indianapolis, IN 46285
Phone Number: 317-433-0117
Email: butterbaughas@lilly.com


Papers:
Modeling a Biphasic Alkylation Reaction Using Phase Transfer Catalyst
Wei Chen, Bristol Myers Squibb; Emily Reiff, Bristol Myers Squibb; Stephen Guzikowski, Bristol Myers Squibb; Xuejun Xu, Bristol Myers Squibb; Olav Lyngberg, Bristol Myers Squibb; John Thornton, Bristol Myers Squibb; Sunil Patel, Bristol Myers Squibb; Chiajen Lai, Bristol Myers Squibb; Michael Randazzo, Bristol Myers Squibb
Reaction Kinetic Modeling in the Development of Bioconjugation Technology
Sa .V Ho, Pfizer Global R&D; John J. Buckley, Pfizer Global R&D; Sydney D. Hoeltzli, Pfizer
Overcoming the Challenges of Bridging and Constriction During Pd-Catalyzed C-N Bond Formation In Microreactors
Ryan L. Hartman, University of Alabama; John R. Naber, Massachusetts Institute of Technology; Stephen L. Buchwald, Massachusetts Institute of Technology; Klavs F. Jensen, Massachusetts Institute of Technology
Reaction NMR: A Quantitative Kinetic Analysis "Probe" for Process Development
David J. am Ende, Pfizer, Inc; Brian Marquez, Pfizer, Inc; Mark Zell, Pfizer, Inc; Pascal Dube, Pfizer, Inc; Robert Krull, Bruker BioSpin; Don Piroli, Bruker BioSpin; Kimberly Colson, Bruker BioSpin; Michael Fey, Bruker BioSpin
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division