Session: Thermodynamics of Protein Folding and Aggregation (2010 Annual Meeting)

Description:

This session seeks submissions focused on experimental and theoretical characterization and prediction of the thermodynamics and mechanism(s) of protein folding, and the role of aggregation as an on- or off-pathway aspect of (un)folding. Aggregation in this context is intended to include both reversible association and net irreversible aggregate formation. The dynamics and aggregation mechanisms of intrinsically disordered proteins and peptides will also be of interest. Preference will be given to presentations that provide insights of general utility, and those focused on relatively complex (un)folding pathways such as multi-domain and natively multimeric proteins.

Sponsor:

Bioengineering

Chair:

Eva Chi
Assistant Professor
University of New Mexico
Chemical and Nuclear Engineering
222 University Blvd NE
Albuquerque, NM 87122
Phone Number: 505-277-2263
Email: evachi@unm.edu

Co-chairs:

Peter M. Tessier
Assistant Professor
Rensselaer Polytechnic Institute
Dept of Chemical & Biological Engineering
Troy, NY 12180
Phone Number: 518-276-2045
Email: tessier@rpi.edu

Inchan Kwon
Assistant Professor
University of Virginia
Chemical Engineering
Charlottesville, VA 22904
Phone Number: 434-924-7778
Email: ik4t@virginia.edu

Troy Cellmer
Post-Doctoral Fellow
National Institutes of Health
Laboratory of Chemical Physics
9000 Rockville Pike
Bethesda, MD 20892
Phone Number: 3014966034
Email: cellmert@niddk.nih.gov

Papers:

750a

Modulating Amyloid-Beta Aggregation and Neurotoxicity by a New Family of Small Molecules
Wei Qi, University of Virginia; H. Edward Wong, University of Virginia; Erik J. Fernandez, University of Virginia; Inchan Kwon, University of Virginia

750b

Structure-Activity Analysis of Small Molecules That Selectively Remodel Soluble Oligomers and Fibrils of Amyloid Aß
Ali Reza A. Ladiwala, Rensselaer Polytechnic Institute; Jason C. Lin, Rensselaer Polytechnic Institute; Shyam Sundhar Bale, Rensselaer Polytechnic Institute; J. Mauricio Mora-Pale, Rensselaer Polytechnic Institute; Jonathan S. Dordick, Rensselaer Polytechnic Institute; Peter M. Tessier, Rensselaer Polytechnic Institute

750c

Inhibition of Amyloid-β Protein Assembly Is Dependent Upon Environmental Conditions: A Quartz Crystal Microbalance Analysis
Joseph A. Kotarek, University of South Carolina; Deborah Soto-Ortega, University of South Carolina; Qian Wang, University of South Carolina; Melissa A. Moss, University of South Carolina

750d

Monomers and Multimers: Role of Quaternary Structure in Regulating Transthyretin-Beta-Amyloid Association
Jiali Du, University of Wisconsin; Regina M. Murphy, University of Wisconsin

Break

750e

A Strategy for Designing a Molecular Probe for Detection of Beta-Amyloid Oligomers
Yang Hu, Polytechnic Institute of New York University; Baihao Su, Polytechnic Institute of New York University; Chung-sei Kim, Polytechnic Institute of New York University; Michael Hernandez, Polytechnic Institute of New York University; Jorge Ghiso, New York University Langone Medical Center; Jin Ryoun Kim, Polytechnic Institute of New York University

750f

Estimating Insulin Nuclei Concentration From Amyloid Fibrils: A Theoretical Approach
Mirco Sorci, Rensselaer Polytechnic Institute; Whitney Silkworth, The Broad Institute of MIT and Harvard; Timothy Gehan, Rensselaer Polytechnic Institute; Georges Belfort, Rensselaer Polytechnic Institute

750g

Kinetics of Aggregation of Polyglutamine and Polyalanine Peptides
Joseph Bernacki, University of Wisconsin; Robert H. Walters, University of Wisconsin; Regina M. Murphy, University of Wisconsin

See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division

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