Session: Mixing and Scale-up/Scale-Down Strategies for the Production of Biopharmaceuticals (2010 Annual Meeting)

Description:

Mixing technology plays a critical role in a large number of steps involved in the production of biopharmaceuticals. Areas of application include fermentation and cell culture processes, recovery operations and formulations. This session encourages the submission of papers in these and related areas addressing advancement, innovation and application of the state of the art in mixing and scale-up/scale-down strategies to the challenges of development and manufacture of biopharmaceuticals.

Sponsor:

North American Mixing Forum

Co-Sponsor(s):

Pharmaceuticals (15b)

Chair:

Alvin W. Nienow
Emeritus Professor of Biochemical Engineering
University of Birmingham
School of Chemical Engineering
Edgbaston
Birmingham B15 2TT
Phone Number: +44 121 414 5325
Email: A.W.Nienow@bham.ac.uk

Co-Chair:

Ashraf Amanullah
Director
Genentech
Oceanside PTD, US Biologics PTD
1 Antibody Way
Oceanside, CA 92056
Phone Number: 760-231-3050
Email: amanullah.ashraf@gene.com

Papers:

476a

Novel Stirred High-Throughput Mini-Bioreactors for Bioprocess Development: Evaluation of Scale-Down From a Typical Bench-Scale Bioreactor
Bhargavi Kondragunta, UMBC; Joao Silva, UMBC; Kurt A. Brorson, Food and Drug Administration (FDA); Antonio R. Moreira, Center for advanced Sensor Technology. University of Maryland, Baltimore County (UMBC); Govind Rao, UMBC

476c

Mixing Uniformity Characterization of 15K Mammalian Cell Culture Bioreactor
Mei Shao, MEDIMMUNE LLC; David Lindsay, MEDIMMUNE LLC; Brian Stamper, MEDIMMUNE LLC; LiYing Yang, MEDIMMUNE LLC; Robert Torregrossa, MEDIMMUNE LLC; Bernd Schmidt, ASTRA ZENECA; Darren Hodson, ASTRA ZENECA; Alistair Boyds, ASTRA ZENECA; Gavin Reynolds, ASTRA ZENECA

476d

A Scale-Down Study of the Impact of Different Stress Parameters On the Growth and Productivity of GSCHO Cell Culture
William H. Scott, University of Birmingham; Colin R. Thomas, University of Birmingham; Chris J. Hewitt, Loughborough University; Gareth Lewis, MedImmune; Alvin W. Nienow, University of Birmingham

476e

Enabling T-Flasks to Improve Bioprocess Development: A Novel Disposable Cell Culture Train From Cell Thawing to Bench-Scale
Jose R. Vallejos, Center for Advanced Sensor Technology. University of Maryland at Baltimore County (UMBC); Kurt A. Brorson, Food and Drug Administration (FDA); Antonio R. Moreira, Center for Advanced Sensor Technology. University of Maryland, Baltimore County (UMBC); Gary J. Lye, University College London; Martina Micheletti, University College London; Govind Rao, Center for Advanced Sensor Technology. University of Maryland, Baltimore County. (UMBC)

476f

Effect of Hydrodynamic Forces On CHO Cells Used Under Industrial Production Conditions
William H. Scott, University of Birmingham; Robert Kiss, Genentech, Inc.; Steven Meier, Genentech, Inc.; Ashraf Amanullah, Genentech; Alvin Nienow, Birmingham University

476g

Directional Oscillatory Shear Index in Orbiting Petri Dishes
Amlan Chakraborty, University of Louisville; M. Keith Sharp, University of Louisville; Venkatakrishna R. Jala, University of Louisville; Haribabu Bodduluri, University of Louisville; R. Eric Berson, University of Louisville

See more of this Group/Topical: North American Mixing Forum

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