Session: Applications of Continuous Processing in Manufacture of Drug Substance / API (2010 Annual Meeting)

Description:

Continuous processing has long been applied successfully in all the chemical/material processing industries such as chemical, petroleum, food, plastics etc. Pharmaceutical manufacturing has been dominated by batch processing concept, where each unit dosage form is identified by a batch and tracked accordingly. Over the last decade, many successful efforts have been reported within pharmaceutical manufacturing involving continuous processing. While drug substance manufacturing has led the way in implementing continuous processing, there is considerable effort being carried out in drug product manufacturing as well. This session invites research efforts and success stories implementing continuous processing for API manufacturing.

Sponsor:

Pharmaceuticals

Co-Sponsor(s):

Particle Production and Characterization (03a), Solids Flow, Handling and Processing (03C)

Chair:

Ecevit Bilgili
Assistant Professor
New Jersey Institute of Technology
Chemical, Biological and Pharmaceutical Engineering
161 Warren St. 150 Tiernan Hall
Newark, NJ 07102
Phone Number: 267-467-4801
Email: bilgece@adm.njit.edu

Co-Chair:

Nancy E. Sever
Reseach Investigator
Abbott Laboratories
Global Formulation Sciences
200 Abbott Park Rd
Abbott Park, IL 60064
Phone Number: 847-935-0866
Email: nancy.sever@abbott.com

Papers:

Introductory Remarks

509a

API Particle Size Engineering by Continuous Crystallization
Derek Griffin, Eli Lilly & Co., Inc.; Martin D. Johnson, Eli Lilly & Co., Inc.; Michael E. Laurila, Eli Lilly & Co., Inc.

509b

Process Development and API Attribute Control of An Amorphous API
Dimitrios Zarkadas, Merck and Co. Inc.; Christopher Pridgen, Merck and Co. Inc.; Vincenzo Liotta, Merck and Co. Inc.

509c

Continuous Nanoparticle Formation and Purification
Robert K. Prud'homme, Princeton University; Varun Kumar, Princeton University

509d

Application of PAT to the Design and Optimization of Plug Flow Crystallization Systems
Steven T. Ferguson, University College Dublin; Brian Glennon, University College Dublin

Break

509e

Continuous Manufacturing of Active Pharmaceutical Ingredients Using Organometallic Heterogeneous Catalysis
Heidrun Gruber-Woelfler, Graz University of Technology; Paul Radaschitz, Graz University of Technology; Peter Feenstra, Graz University of Technology; Georg J. Lichtenegger, Graz University of Technology; Eleonora Polo, C.N.R.-ISOF Sez. Ferrara; Johannes Khinast, Graz University of Technology

509f

Continuous Flow Reactors for Benign Production of Pharmaceuticals and Pharmaceutical Intermediates
Olga Y. Dzenis, Georgia Institute of Technology; Gregory Marus, Georgia Institute of Technology; Kristen K. Kitagawa, Georgia Institute of Technology; Kyle Flack, Georgia Institute of Technology; Pamela Pollet, Georgia Institute of Technology; Charles A. Eckert, Georgia Institute of Technology; Charles Liotta, Georgia Institute of Technology; William DuBay, AMPAC Fine Chemicals; Kent Richman, AMPAC Fine Chemicals

509g

Preparation of API-Crystals in a Continuously Seeded Tubular Crystallizer
Rafael J. P. Eder, Graz University of Technology; Elisabeth Schmitt, Graz University of Technology; Julia Grill, Graz University of Technology; Stefan Radl, Graz University of Technology; Heidrun Gruber-Woelfler, Graz University of Technology; Johannes Khinast, Graz University of Technology

See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division

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