Session: Biophysical Behavior of Pharmaceutical Proteins in Processing, Storage and Delivery Environments I (2012 Annual Meeting)

Description:

Processing, storage and delivery can subject pharmaceutical proteins to physical and chemical stresses, decreasing biological activity. In this session we will explore both the biophysical characterization of pharmaceutical proteins in process-, storage- and delivery-relevant environments and processing-, formulation- and protein engineering-based manipulation of biophysical behavior to preserve biological activity in these environments.

Sponsor:

Biomedical Applications of Chemical Engineering

Chair:

Todd M. Przybycien
Carnegie Mellon University
Department of Chemical Engineering and Department of Biomedical Engineering
Pittsburgh, PA 15213
Fax Number: (412) 268 6913
Email: todd@andrew.cmu.edu

Co-Chair:

Robert D. Tilton
Professor
Carnegie Mellon University
Chemical Engineering and Biomedical Engineering
Doherty Hall 3111
Pittsburgh, PA 15213
Phone Number: 412-268-1159
Email: tilton@andrew.cmu.edu

Papers:

262a

Protein Behavior At Pharmaceutically-Relevant Microparticle Interfaces
Theodore W. Randolph, University of Colorado

262b

Single Molecule Protein Dynamics and Aggregation At the Oil-Water Interface
Robert Walder, University of Colorado at Boulder; Daniel K. Schwartz, University of Colorado at Boulder

262c

Does Poly(ethylene glycol) Conjugation Protect Proteins From Conformational Change During Emulsion-Based Microsphere Encapsulation?
Adam L. Canady, Carnegie Mellon University; Todd M. Przybycien, Carnegie Mellon University; Robert D. Tilton, Carnegie Mellon University

Break

262d

Structure and Stability of Pol(L-lysine)/Hyaluronan Thin Films As Nanoreservoirs for the Bone Morphogenetic Protein-2
Flora Gilde, Grenoble Institute of Technology; Ofelia Maniti, Grenoble Institute of Technology; Raphael Guillot, Grenoble Institute of Technology; Jorge Almodovar, Grenoble Institute of Technology; Catherine Picart, Grenoble Institute of Technology

262e

Formulation of Bovine Serum Albumin Encapsulated Cal-Alginate Microspheres by Electrodispersion for a Simulated Release in a Gastric Fluid
Yinyan Zhao, Bioanalytical Systems, Inc; Fuyue Li, Georgia Institute of Technology; Michael T. Harris, Purdue University

262f

Design of a Vessel to Facilitate Rapid Thawing of a Labile Protein
Robert Large, Grifols, Inc.; Ajoy K. Velayudhan, Grifols, Inc.

See more of this Group/Topical: Topical 7: Biomedical Applications of Chemical Engineering

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