Session: Fundamentals of Protein Folding in Diseases (2012 Annual Meeting)

Description:

This session seeks submissions focused on experimental and theoretical characterization and prediction of the thermodynamics and mechanism(s) of protein folding, and the role of aggregation as an on- or off-pathway aspect of (un)folding. Aggregation in this context is intended to include both reversible association and net irreversible aggregate formation. The dynamics and aggregation mechanisms of intrinsically disordered proteins and peptides will also be of interest. Preference will be given to presentations that provide insights of general utility, and those focused on relatively complex (un)folding pathways such as multi-domain and natively multimeric proteins.

Sponsor:

Bioengineering

Chair:

Inchan Kwon
Assistant Professor
University of Virginia
Department of Chemical Engineering
Charlottesville, VA 22904
Phone Number: 434-243-1822
Fax Number: 434-982-2658
Email: ik4t@virginia.edu

Co-Chair:

Shannon Servoss
University of Arkansas
Ralph E. Martin Department of Chemical Engineering
Fayetteville, AR 72701
Email: sservoss@uark.edu

Papers:

214a

Effect of Engineered Transthyretin Mutants On Beta-Amyloid Aggregation and Toxicity
Dennis T. Yang, University of Wisconsin-Madison; Patricia C. Cho, University of Wisconsin-Madison; Regina M. Murphy, University of Wisconsin-Madison

214b

Modulation of Amyloid-Beta Aggregation and Cytotoxicity by Halogenated Small Molecules
H. Edward Wong, University of Virginia; Jacob Irwin, University of Virginia; Inchan Kwon, University of Virginia

214c

Conformational Differences Between Beta-Amyloid Oligomers of Similar Size and Dissimilar Toxicity
Ali Reza A. Ladiwala, Rensselaer Polytechnic Institute; Peter M. Tessier, Rensselaer Polytechnic Institute

214d

Inhibition of Alzheimer's-Associated Aβ Aggregation by Gold Nanoparticles
Kelly A. Moore, University of South Carolina; Deborah Soto-Ortega, University of South Carolina; Mihyun Lim, University of South Carolina; Kayla Pate, University of South Carolina; Kaliah Jackson, SC State University; Sam Lohse, University of Illinois at Urbana-Champaign; Rahina Mahtab, SC State University; Catherine Murphy, University of Illinois at Urbana-Champaign; Melissa Moss, University of South Carolina

214e

Effect of Co-Solutes On the Aggregation of the Model Amyloid Protein Insulin
Brian Murray, Rensselaer Polytechnic Institute; Mirco Sorci, Rensselaer Polytechnic Institute; Zhongli Zheng, University of Notre Dame; Y. Elaine Zhu, University of Notre Dame; Georges Belfort, Rensselaer Polytechnic Institute

214f

Hofmeister Effects and Amyloid Structure of Sup35
Jonathan Rubin, Georgia Institute of Technology; Sven H. Behrens, Georgia Institute of Technology; Yury O. Chernoff, Georgia Institute of Technology; Andreas S. Bommarius, Georgia Institute of Technology

214g

Modulation of Amyloid Aggregation by Engineering the Sequence Connecting Beta-Strand Forming Domains
Yang Hu, Polytechnic Institute of New York University; Michael Hernandez, Polytechnic Institute of New York University; Ahra Ko, Polytechnic Institute of New York University; Jin Ryoun Kim, Polytechnic Institute of New York University

214h

Elucidating the Role of N-Terminal Huntingtin Fragment in Polyglutamine Aggregation
Diwakar Shukla, Massachusetts Institute of Technology; Vijay Pande, Stanford University

See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division - See also TI: Comprehensive Quality by Design in Pharmaceutical Development and Manufacture

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