Session: Protein Engineering II - Techniques (2012 Annual Meeting)

Description:

The focus of this session is to reflect the latest advances in protein engineering and design. Suggested topics include, but are not limited to: (1) Development of high throughput screen/selection for protein engineering; (2)Development of novel protein engineering methods; (3) protein engineering via directed evolution; (4) computational protein engineering and design.

Sponsor:

Bioengineering

Chair:

Bradley C. Bundy
Assistant Professor
Brigham Young University
Chemical Engineering
350S Clyde Building
Provo, UT 84602
Email: bundy@byu.edu

Co-Chair:

Karl E. Griswold
Assistant Professor
Dartmouth College
Thayer School of Engineering
HB 8000
Hanover, NH 03755
Fax Number: 603-646-2277
Email: Karl.E.Griswold@Dartmouth.edu

Papers:

110a

A Platform for Antibody Engineering Against Membrane Protein Targets Using Detergent-Solubilized Cell Lysates As Antigen Sources
Yong Ku Cho, University of Wisconsin-Madison; Ben J. Tillotson, University of Wisconsin-Madison; Inigo de Larrinoa, University of the Basque Country; Eric V. Shusta, University of Wisconsin-Madison

110b

Directed Evolution Strategies for Escaping Local Fitness Maxima
Barrett Steinberg, Johns Hopkins University; Marc Ostermeier, Johns Hopkins University

110c

Enhancing FLI-TRAP for Rapid Isolation of Solubility and Affinity Matured Antibodies
Dujduan Waraho, Cornell University; Matthew P. DeLisa, Cornell University

110d

Development of a High-Throughput Screen for Directed Evolution of Inteins
Michael J. Coolbaugh, The Ohio State University; David W. Wood, the Ohio State University

110e

Mod Designer: A Robust Optimization Framework for the Design of Proteins with Post-Translational Modifications and Unnatural Amino Acids and Its Applications to Cancer
George A. Khoury, Princeton University; James Smadbeck, Princeton University; Christodoulos A. Floudas, Princeton University

110f

A Novel Amine Dehydrogenase for the Selective Production of Chiral Amines
Michael J. Abrahamson, Georgia Institute of Technology; Eduardo Vazquez-Figueroa, Georgia Institute of Technology; Nicholas Woodall, Georgia Institute of Technology; Jeffery Moore, Merck and Company, Inc.; Andreas S. Bommarius, Georgia Institute of Technology

110g

A Platform for the Discovery of Proteasomal Degradation Activators
Wenting Zhao, Rice University; Laura Segatori, Rice University

110h

Quantitative Functional Single-Cell Characterization of Surface Display of Recombinant Proteins Using A Bacterial Autotransporter
Balakrishnan Ramesh, University of Houston; Patrick C. Cirino, University of Houston; Navin Varadarajan, University of Houston

See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division - See also TI: Comprehensive Quality by Design in Pharmaceutical Development and Manufacture

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