Session: Bioseparations and Downstream Processing (2012 Annual Meeting)

Description:

This session will focus on highlighting the latest advances in downstream processing relevant to purification/polishing operations including rapid process development, improved efficiency, cost reduction, integration of operations, handling of high titre streams and sustainability issues. Topics to be covered include, but are not limited to: Uni- and multi-modal chromatography, membrane-based separations and filtration, extraction, precipitation and crystallization.

Sponsor:

Bioengineering

Co-Sponsor(s):

Bio Separations (02G)

Chair:

Caryn L. Heldt
Assistant Professor
Michigan Technological University
Department of Chemical Engineering
1400 Townsend Dr.
Houghton, MI 49931
Phone Number: 906-487-1134
Email: heldt@mtu.edu

Co-Chair:

Peter Martin
Lecturer
The University of Manchester
School of Chemical Engineering and Analytical Science
The Mill
Manchester M60 1QD
Fax Number: +44 (0)161 306 9321
Email: P.Martin@manchester.ac.uk

Papers:

15a

Chemical Grafting of Chromatographic Resins for the Selective Adsorption of Pegylated Proteins
Aguilar Oscar, Tec de Monterrey; Hernández-Martínez Agustín, Tec de Monterrey

15b

Control of Intein-Mediated Recombinant Protein Purification in a Chinese Hamster Ovary (CHO) Cell Expression System
Tzu-Chiang Han, The Ohio State University; David W. Wood, The Ohio State University

15c

Excipients Removal by Capto S Chromatography and UF/DF Process Development for High-Concentration Drug Substance Production
Gregory Waszak, Pfizer Inc; Larry Determan Jr., Pfizer Inc.; Joseph Martin Jr., Pfizer Inc

15d

Designing in Process Robustness: Minimizing Proteolysis Through Analytical and Chromatographic Tools
Janelle Konietzko, Merck & Co.; Andrew Englehart, Merck & Co.; Thomas Svab, Merck & Co.; Adam Kristopeit, Merck & Co.; Marc Wenger, Merck & Co., Inc.; Michael E. Laska, Merck & Co.; Aaron R. Goerke, Merck & Co.

15e

Proteomics Based Multivariate Random Forest Method for Prediction of Protein Separation Behavior During Downstream Purification
Ryan K. Swanson, Iowa State University; Ruo Xu, Iowa State University; Dan Nettleton, Iowa State University; Charles E. Glatz, Iowa State University

15f

Virus Purification by Aqueous Two Phase Extraction System
K. Saagar Vijayaragavan, Michigan Technological University; Caryn L. Heldt, Michigan Technological University

15g

The Effect of Single-Use Retentate Recycle Bag Design On Diafiltration Efficiency
David M. Bohonak, EMD Millipore Corporation; Elizabeth Goodrich, EMD Millipore Corporation

15h

Flux Enhancement in Recycling Cellulase From Enzymatic Hydrolyzate of Acid Treated Wheat Straw by Electroultrafiltration
Guoqiang Chen, Institute of Process Engineering, Chinese Academy of Sciences; Yinhua Wan, Institute of Process Engineering, Chinese Academy Of Sciences

See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division - See also TI: Comprehensive Quality by Design in Pharmaceutical Development and Manufacture

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