This preliminary program is subject to change.

Gene Regulation Engineering


Description:
The regulation of gene expression dictates cellular processes in all forms of life with broad applications in biotechnology and medicine. Controlling life's processes thus requires a detailed understanding of the underlying gene regulatory mechanisms as well as approaches to manipulate existing regulatory interactions and to introduce new ones. For this session, we invite high-quality presentations that improve our ability to understand, predict, and control gene expression through the quantitative characterization of its many molecular interactions. Presentations on the construction and application of gene regulatory systems also will be considered. Potential topics include protein-based and RNA-based regulation at the levels of transcription, translation, RNA stability, and RNA processing that span single-gene and genome-wide interactions. Presentations that address gene regulation in industrial and medically relevant organisms particularly are encouraged.

Sponsor:
Bioengineering


Chair:
Chase L. Beisel
Assistant Professor
North Carolina State University
Department of Chemical and Biomolecular Engineering
911 Partners Way
Raleigh, NC 27695-7905
Fax Number: 919-515-3465
Email: cbeisel@ncsu.edu

Co-chairs:
Howard Salis
Assistant Professor
Pennsylvania State University
Chemical Engineering / Biological Engineering
University Park, PA 16802
Email: salis@psu.edu

Yvonne Chen
Junior Fellow
Harvard Society of Fellows
78 Mt. Auburn Street
Cambridge, MA 02138
Email: yvonne_chen@hms.harvard.edu


Papers:
Enabling Transcriptional Control in Saccharomyces Cerevisiae Utilizing a Synthetic Hybrid Promoter Engineering Approach
John Blazeck, University of Texas at Austin; Hal Alper, The University of Texas at Austin
Coordinated Induction of Multi-Gene Pathways in Saccharomyces Cerevisiae
Jing Liang, University of Illinois at Urbana-Champaign; Jonathan Ning, University of Illinois at Urbana-Champaign; Huimin Zhao, University of Illinois at Urbana-Champaign
Quantitative Analysis of Translational Coupling in Escherichia Coli
Shuyan Zhang, University of Illinois at Urbana Champaign; Lon Chubiz, University of Illinois; Christopher V. Rao, University of Illinois, Urbana Champaign
A Biophysical Model of Structured Ribosomal Standby Sites and Their Effect On the mRNA Translation Rate
Amin Espah Borujeni, Pennsylvania State University; Howard Salis, Pennsylvania State University
Exploiting Thermodynamics of mRNA Secondary Structure for Antisense Design
Erik Johnson, University of Connecticut; Ranjan Srivastava, University of Connecticut
Variants of the Quorum-Sensing Repressor Modulated Promoter, Pesar, Alter Amplitude, Signal Sensitivity and Switch-Like Behavior
Jasmine Shong, Rensselaer Polytechnic Institute; Cynthia H. Collins, Rensselaer Polytechnic Institute
Robustness and Energetic Analysis of an Extended Pluripotency MODEL of Embryonic STEM CELLS Transcriptional Network
Deepak Nagrath, Rice University; Marco Avila, Massachusetts General Hospital/Shriners Burn Hospital/Harvard Medical School; Martin L. Yarmush, MGH/Harvard Medical School
Dose-Dependent p21(Cip1/Waf1) Cell Cycle Regulation
K. Wesley Overton, Stanford University; Clifford L. Wang, Stanford University