This preliminary program is subject to change.

Applications of Continuous Processing in Manufacture of Pharmaceuticals: Drug Product


Description:
Pharmaceutical manufacturing has been dominated by the batch processing concept, where each unit dosage form is produced in a batch and tracked accordingly. However, over the last decade continuous manufacturing of active pharmaceutical ingredients (APIs) and drug products has become increasingly important as there are many advantages, such as reduced capital and operational costs, as well as real-time quality control for increased process reliability and reproducibility. Thus, this session invites speakers to present their scientific efforts in the area of continuous processing for API and drug product manufacturing.

Sponsor:
Pharmaceuticals
Co-Sponsor(s):
Particle Production and Characterization (03a)


Chair:
William R. Ketterhagen
Principal Scientist
Pfizer Inc.
Worldwide Research and Development
Groton, CT 06340
Email: william.ketterhagen@pfizer.com

Co-Chair:
Stelios Tsinontides
Sr. Dir., Worldwide Process Development
Cephalon, Inc.
Global Process Development
145 Brandywine Parkway
West Chester, PA 19380
Phone Number: 610-883-5659
Email: stsinont@cephalon.com


Papers:
Continuous Pharmaceutical Hot-Melt Extrusion and Hot-Die Face Pelletizing
Daniel Treffer, Graz University of Technology; Andreas Eitzlmayr, Graz University of Technology; Clemens-Michael Smola, Research Center Pharmaceutical Engineering GmbH; Gerold Koscher, Research Center Pharmaceutical Engineering GmbH; Eva Roblegg, University of Graz; Johannes G. Khinast, Graz University of Technology
Predictive Modeling of Hot Melt Extruders
Andreas Eitzlmayr, Graz University of Technology; Daniel Treffer, Graz University of Technology; Gudrun Hoerl, Research Center Pharmaceutical Engineering GmbH; Sarah Windhab, Research Center Pharmaceutical Engineering GmbH; Gerold Koscher, Research Center Pharmaceutical Engineering GmbH; Johannes G. Khinast, Graz University of Technology
Foam Granulation Extrusion: A Novel Method to Continuous Wet Granulation of Powder Drug Formulations
Michael R. Thompson, McMaster University; Sharleen Weatherley, McMaster University; Rohan Pukadyil, McMaster University; Paul Sheskey, The Dow Chemical Company
Powder Feeder Pairing with Downsteam Continuous Mixer
William E. Engisch Jr., Rutgers, The State University of New Jersey; Fernando J. Muzzio, Rutgers, The State University of New Jersey
Powder Lubrication in a Continuous Mixing Process
Daniel O. Blackwood, Pfizer Worldwide Research and Development; Bruce C. MacDonald, Pfizer Worldwide Research and Development; Joseph Kushner IV, Pfizer Worldwide Research and Development; Bruno C. Hancock, Pfizer Worldwide Research and Development; Yang A. Liu, Pfizer Worldwide Research and Development
Effect of Paddle Shape On Flow of Powder Through Feed Frames On Rotary Tablet Presses
G. Singh, University of Leicester; J. Givand, Merck, Sharp & Dohme; P. Rajniak, Merck, Sharp & Dohme; R. Chern, Merck, Sharp & Dohme; S.D. Reynolds, Merck, Sharp & Dohme; I.C. Sinka, University of Leicester
Supply Chain Analysis of Continuous Pharmaceutical Manufacturing
Arul Sundaramoorthy, Massachusetts Institute of Technology; James M.B. Evans, Massachusetts Institute of Technology; P.I. Barton, Massachusetts Institute of Technology