This preliminary program is subject to change.

Applications of Continuous Processing in Manufacture of Pharmaceuticals: Drug Substance


Description:
Pharmaceutical manufacturing has been dominated by the batch processing concept, where each unit dosage form is produced in a batch and tracked accordingly. However, over the last decade continuous manufacturing of active pharmaceutical ingredients (APIs) and drug products has become increasingly important as there are many advantages, such as reduced capital and operational costs, as well as real-time quality control for increased process reliability and reproducibility. Thus, this session invites speakers to present their scientific efforts in the area of continuous processing for API and drug product manufacturing.

Sponsor:
Pharmaceuticals


Chair:
Ilgaz Akseli
Senior Scientist
Boehringer Ingelheim
R&D Pharmaceutical Development
900 Ridgebury Rd
Ridgefield, CT 06877
Phone Number: 203-791-6703
Email: ilgaz.akseli@boehringer-ingelheim.com

Co-Chair:
Daniel Patience
Teva Pharmaceuticals
Chemical Process Research & Development
Malvern, PA 19355
Email: daniel.patience@tevapharm.com


Papers:
A Safer, Greener Grignard
Rick Spencer, Eli Lilly and Company
Continuous High Pressure Vapor/Liquid PFR Sampling System with On-Line HPLC
Wei-Ming Sun, Eli Lilly &Co., Inc.; Martin D. Johnson, Eli Lilly and Company; Edward Sheldon, Eli Lilly & Co.
Characterization and Selection of Continuous Plug Flow Reactors in Pharmaceutical Development
Brian D. Haeberle, Eli Lilly and Company; Martin D. Johnson, Eli Lilly and Company; Scott A. May, Eli Lilly & Co.; Timothy Braden, Eli Lilly &Co., Inc.; Ed Plocharczyk, D&M Continuous Solutions LLC
Multi Scale Flowsheet Simulation for the Purification and Processing of Active Pharmaceutical Ingredients
Maitraye Sen, Rutgers, The State University of New Jersey; Anwesha Chaudhury, Rutgers, The State University of New Jersey; Joyce John, Rutgers, The State University of New Jersey; Ravendra Singh, Rutgers, The State University of New Jersey; Rohit Ramachandran, Rutgers, The State University of New Jersey
Adaptive Continuous Template Based Novel Manufacturing Technique for Faster Manufacturing of New APIs for Clinical Trials
Ravendra Singh, Technical University of Denmark; Krist V. Gernaey, Technical University of Denmark; Rafiqul Gani, Technical University of Denmark; John M. Woodley, Technical University of Denmark
Sustainable and Continuous Reduction of Amides
Kathryn Rix, Imperial College London; Geoffrey Kelsall, Imperial College London; Klaus Hellgardt, Imperial College London; Mimi Hii, Imperial College London
Benign Alkylation of Amines by Alcohols (AAA)
Luka Tallon, Imperial College London; Klaus Hellgardt, Imperial College London; Mimi Hii, Imperial College London