This preliminary program is subject to change.

Solid Form Selection: Cocrystals, Salts, Solvates, Polymorphs and Beyond


Description:
Continuous improvement of the physicochemical properties of active pharmaceutical ingredients (APIs) such as solubility, bioavailability, dissolution rate, stability, hygroscopicity, crystallinity and taste, represents an emerging area of research and development. This session focuses on the selection of solid forms including cocrystals, salts, solvates and polymorphs in crystallization processes, as well as the screening, predicting, manipulating and controlling techniques for such product selection.

Sponsor:
Crystallization and Evaporation


Chair:
Ann M. Czyzewski
Senior Scientist I
Abbott Laboratories
1401 Sheridan Rd.
North Chicago, IL 60064
Email: ann.czyzewski@abbott.com

Co-Chair:
Fang Wang
Senior Research Scientist
Gilead Sciences
Chemical Development
333 Lakeside drive
Foster City, CA 94404
Email: fang.wang@gilead.com


Papers:
Identification, Characterization and Development of a Betaine Co-Crystal for a Pharmaceutical Compound
Bing-Shiou Yang, Boehringer Ingelheim Pharmaceuticals, Inc.; Zhibin Li, Boehringer Ingelheim Pharmaceuticals, Inc.; Ka Yip, Boehringer Ingelheim Pharmaceuticals, Inc.; Soojin Kim, Boehringer Ingelheim Pharmaceuticals, Inc.; Daniel Fandrick, Boehringer Ingelheim Pharmacuticals, Inc.; Jeff Song, Boehringer Ingelheim Pharmacuticals, Inc.; Nathan Yee, Boehringer Ingelheim Pharmaceuticals, Inc.; Chris Senanayake, Boehringer Ingelheim Pharmaceuticals, Inc.
Polymorph Screening Using Self-Assembled Monolayers and Scale-up of Metastable Forms
Jie Chen, Massachusetts Institute of Technology; Allan S. Myerson, Massachusetts Institute of Technology
Transformation of an Amorphous API to Crystalline Hydrate and Co-Crystals
Fang Wang, Gilead Sciences; Ernest Carra, Gilead Sciences; Anna Chiu, Gilead Sciences; Jesper Jernelius, Gilead Sciences
Solvent Compatible Microfluidic Platforms for Solid Form Screening of Pharmaceutical Parent Compounds
Sachit Goyal, University of Illinois at Urbana Champaign; Yuchuan Gong, Abbott Laboratories; Geoff G.Z. Zhang, Abbott Laboratories; Paul J.A. Kenis, University of Illinois at Urbana Champaign
Computational Crystal Structure Prediction of Organic Molecules
Erik E. Santiso, Imperial College London,Center for Process Systems Engineering; Andrei V. Kazantsev, Imperial College London,Center for Process Systems Engineering; Manolis Vasileiadis, Imperial College London,Center for Process Systems Engineering; Claire S. Adjiman, Imperial College London,Center for Process Systems Engineering; Constantinos C. Pantelides, Imperial College London,Center for Process Systems Engineering
Computational Study of Polymorph Selection in Glycine
Nathan Duff, University of California; Baron Peters, University of California Santa Barbara
Influence of Polymeric Additives On the Nucleation Kinetics, Growth, and Polymorph Selectivity of Calcium Salts
Mitali China, University at Buffalo - The State University of New York (SUNY); Priyanka Rajaram, University at Buffalo - The State University of New York (SUNY); Marina Tsianou, University at Buffalo - The State University of New York (SUNY)
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