This preliminary program is subject to change.

Alternative Crystallization Technologies and Case Studies of Crystallization Processes


Description:
As in-situ particle engineering becomes a focus of industrial crystallization, alternative technologies are being developed in order to predictably control particle properties. Increasing interest towards continuous crystallization is also contributing to the need for new crystallization technologies. Standard batch crystallizations are generally performed in a stirred tank and continuous crystallizations are being developed in stirred tanks or in tubular crystallizers. Alternative crystallization technologies can include non-conventional equipment/crystallizer configurations in order to perform batch/continuous crystallizations. Many current technologies under development focus on particle micronization and/or nano-crystallization which may include; micro-reactors, impinging jets, or crystallization from an emulsion. Submissions to this session can focus on (1) alternative crystallization equipment, processing technologies, or other unique approaches to carrying out a crystallization, or (2) novel approaches for carrying out crystallization or post-crystallization processing for desired product characteristics. The papers should use case studies and specific examples to illustrate the new methods.

Sponsor:
Crystallization and Evaporation
Co-Sponsor(s):
Solids Flow, Handling and Processing (03C), Pilot Plants (12b)


Chair:
Bing-Shiou Yang
Principal Scientist
Boehringer Ingelheim Pharmaceuticals, Inc.
900 Ridgebury Rd./P.O. Box 368
Ridgefield, CT 06877-0368
Email: bing-shiou.yang@boehringer-ingelheim.com

Co-chairs:
Michael A. Lovette
Associate Senior Consultant Engineer
Eli Lilly and Company
Chemical Product R&D
Lilly Corporate Center
Indianapolis, IN 46285
Phone Number: 617-645-4336
Email: mlovette@lilly.com

Bruce D. Hook
The Dow Chemical Company
B-4810, 2301 N. Brazosport Blvd.
Freeport, TX 77541
Phone Number: 979 238 1291
Fax Number: 979-238-2347
Email: BDHook@dow.com


Papers:
Layer Melt Crystallization of Long-Chain Aldehydes From Hydroformylation Processes
Thorsten Beierling, Technische Universität Dortmund; Gabriele Sadowski, Technische Universität Dortmund
Hybrid Filtration-Drying-Dissolution Device for Compact Pharmaceutical Manufacturing System
Shin Yee Wong, Massachusetts Institute of Technology; Jie Chen, Massachusetts Institute of Technology; Allan S. Myerson, Massachusetts Institute of Technology
Design and Characterization of a Continuous Stirred Tank Crystallizer
Gary Morris, University College Dublin; Guangyang Hou, University College Dublin; Mark Barrett, University College Dublin; Brian Glennon, University College Dublin
X-Ray Compatible Microfluidic Platforms for On-Chip Structure Determination of Membrane Proteins
Sudipto Guha, University of Illinois at Urbana-Champaign; Ashtamurthy Pawate, University of Illinois at Urbana-Champaign; Sarah L. Perry, University of Illinois at Urbana-Champaign; Paul J.A. Kenis, University of Illinois at Urbana-Champaign
Investigation of a Counter-Current Crystallization Process for Separation of Systems Forming Solid Solutions
Erik Temmel, Max Planck Institute for Dynamics of Complex Technical Systems; Sebastian Wloch, Max Planck Institute for Dynamics of Complex Technical Systems; Uwe Müller, Hapila Gera GmbH; Detlef Grawe, Jesalis Pharma GmbH; Robert Eilers, Hapila Gera GmbH; Heike Lorenz, Max Planck Institute for Dynamics of Complex Technical Systems; Andreas Seidel-Morgenstern, Max-Planck Institute for Dynamics of Complex Technical System
Designing a Fit-for-Purpose Agglomeration Method for Pharmaceutical Crystals
Chenchi Wang, Bristol-Myers Squibb Company; Daniel Hsieh, Bristol-Myers Squibb Company; Mario Hubert, Bristol-Myers Squibb Company; Chiajen J. Lai, Bristol-Myers Squibb Company
Utilization of Population Balance Models to Develop a Continuous Crystallization Process; Determination of Crystallization Kinetics
Christopher L. Burcham, Eli Lilly and Company; Michael A. Lovette, Eli Lilly and Company; Christopher S. Polster, Eli Lilly and Company; Sean K. Bermingham, Process Systems Enterprise; Hassan Mumtaz, Process Systems Enterprise
Utilization of Population Balance Models to Develop a Continuous Crystallization Process; Process Design Using Optimization
Christopher L. Burcham, Eli Lilly and Company; Michael A. Lovette, Eli Lilly and Company; Christopher S. Polster, Eli Lilly and Company; Sean K. Bermingham, Process Systems Enterprise; Hassan Mumtaz, Process Systems Enterprise
See more of this Group/Topical: Separations Division