This preliminary program is subject to change.

Crystallization Process Development


Description:
Crystallization is an important unit operation in the chemical industry, especially in the isolation and purification of pharmaceuticals and other fine chemicals. However, developing a crystallization process is a challenging problem in itself. The mixture to be separated often involves multiple components, and it is crucial that the solids are consistently obtained in the right polymorphic forms, compounds, adducts, or solvates. The particles need to be in the right size distribution in order to avoid problems such as difficult filtration or high residual impurity content. This session is open to contributions related to theoretical as well as practical approaches to crystallization process development. These include methods, techniques, or tools that can lead to faster and better development of crystallization processes, as well as real-life case studies or examples on how crystallization processes are developed. Papers which describe the design and operation of batch or continuous crystallization processes are particularly encouraged.

Sponsor:
Process Research and Innovation
Co-Sponsor(s):
Crystallization and Evaporation (02B)


Chair:
Seth Huggins
Amgen
Chemical Process R&D
One Amgen Center Drive
Thousand Oaks, CA 91320
Phone Number: 805-447-3710
Email: shuggins@amgen.com

Co-Chair:
Greg Sukay
Dir Process Development
Amgen
Chemical Process R&D
Email: gsukay@amgen.com


Papers:
Amine-Functionalized Metal-Organic Framework Crystallization Process Design
Paul M. Schoenecker, Georgia Institute of Technology; Grace A. Belancik, Georgia Institute of Technology; Bogna Grabicka, Georgia Institute of Technology; William J. Koros, Georgia Institute of Technology; Krista S. Walton, Georgia Institute of Technology
The Role of Meso-Mixing in Anti-Solvent Crystallization Processes
Des O'Grady, METTLER TOLEDO; Mark Barrett, University College Dublin; Brian Glennon, University College Dublin; Eoin Casey, University College Dublin
Crystallization of Active Pharmaceutical Ingredients in Scrapped Surface Crystallizers
Jie Chen, Massachusetts Institute of Technology; Shin Yee Wong, Massachusetts Institute of Technology; Allan S. Myerson, Massachusetts Institute of Technology
Continuous Enantioseparation in a MSMPR Crystallizer – Experimental and Theoretical Investigation of Different Process Conditions
Kamila Galan, Max Planck Institute for Dynamics of Complex Technical Systems; Martin Peter Elsner, Georg Simon Ohm University of Applied Sciences; Andreas Seidel-Morgenstern, Max-Planck Institute for Dynamics of Complex Technical System
Continuous Crystallization Process Development
Haitao Zhang, Massachusetts Institute of Technology; Justin Quon, Massachusetts Institute of Technology; James M.B. Evans, Massachusetts Institute of Technology; Allan S. Myerson, Massachusetts Institute of Technology; Bernhardt L. Trout, Massachusetts Institute of Technology
See more of this Group/Topical: Process Development Division