This preliminary program is subject to change.

Metabolic Engineering and Bioinformatics II


Description:
Metabolic engineering is the targeted improvement of the cellular metabolic phenotype using recombinant DNA technology. Improvements often require characterization of the existing and heterologous metabolic networks using both experimental and computational techniques. Abstracts describing new developments in these topics are sought, and those incorporating both mathematical modeling and experimental aspects are particularly encouraged. Example areas include quantification of metabolic fluxes, inverse metabolic engineering, production of novel products, application of evolutionary techniques, construction of metabolic models from genomic data, and incorporation of microarray and proteomic data and mathematical modeling of metabolism. The session is open to papers focused on any type of organism.

Sponsor:
Bioengineering


Chair:
Brian F. Pfleger
University of Wisconsin Madison
Chemical and Biological Engineering
3629 Engineering Hall
Madison, WI 53706
Phone Number: 608-890-1940
Email: pfleger@engr.wisc.edu

Co-Chair:
Howard Salis
Assistant Professor
Pennsylvania State University
Chemical Engineering / Biological Engineering
University Park, PA 16802
Email: salis@psu.edu


Papers:
Combinatorial Design of Hydrolysate-Tolerant E. Coli Mutants
Tirzah Y. Glebes, University of Colorado at Boulder; Nicholas R. Sandoval, University of Colorado at Boulder; Nanette R. Boyle, University of Colorado at Boulder; Ryan T. Gill, University of Colorado at Boulder
Complete-MFA: Complementary Parallel Labeling Experiments Technique for Metabolic Flux Analysis
Maciek R. Antoniewicz, University of Delaware; Robert Leighty, Univerisity of Delaware
Metabolic Engineering of Rhizopus Oryzae: Effects of Overexpressing Fumr Genes On Fumaric Acid Biosynthesis From Glucose
Baohua Zhang, The Ohio State University; Kun Zhang, The Ohio State University; Shang-Tian Yang, Ohio State University
Flux Regulation At a Primary Metabolic Node: Lessons for Acetyl-CoA Derived Products
Karthik Sekar, Northwestern University; Keith E.J. Tyo, Northwestern University
Estimation of Genome-Scale Metabolic Fluxes From Tn-Seq Single Mutant Growth Measurements
Hong Yang, University of Minnesota; Elias W. Krumholz, University of Minnesota; Evan D. Brutinel, University of Minnesota; Jeffrey A. Gralnick, University of Minnesota; Igor G.L. Libourel, University of Minnesota
Reconstruction of Integrated Metabolic and Transcriptional Regulatory Network Models As a Platform for Metabolic Engineering
Joonhoon Kim, University of Wisconsin-Madison; Jennifer L. Reed, University of Wisconsin-Madison
Flux and Reflux: Metabolite Back-Mixing in Plant Cell Suspensions and Its Implications On Isotope-Assisted Metabolic Flux Analysis
Xiaofeng Zhang, University of Maryland, College Park; Ashish Misra, University of Maryland; Shilpa Nargund, University of Maryland; Gary D. Coleman, University of Maryland, College Park; Ganesh Sriram, University of Maryland
A Second-Generation Genome Scale Model for Clostridium Acetobutylicum
Patrick F. Suthers, The Pennsylvania State University; Costas D. Maranas, The Pennsylvania State University