Session: Biophysical Behavior of Pharmaceutical Proteins in Processing, Storage and Delivery Environments II (2012 Annual Meeting)

Description:

Processing, storage and delivery can subject pharmaceutical proteins to physical and chemical stresses, decreasing biological activity. In this session we will explore both the biophysical characterization of pharmaceutical proteins in process-, storage- and delivery-relevant environments and processing-, formulation- and protein engineering-based manipulation of biophysical behavior to preserve biological activity in these environments.

Sponsor:

Biomedical Applications of Chemical Engineering

Co-Sponsor(s):

Bioengineering (15c)

Chair:

Todd M. Przybycien
Carnegie Mellon University
Department of Chemical Engineering and Department of Biomedical Engineering
Pittsburgh, PA 15213
Fax Number: (412) 268 6913
Email: toddp@andrew.cmu.edu

Co-Chair:

Robert D. Tilton
Professor
Carnegie Mellon University
Chemical Engineering and Biomedical Engineering
Doherty Hall 3111
Pittsburgh, PA 15213
Phone Number: 412-268-1159
Email: tilton@andrew.cmu.edu

Papers:

408a

Stimulus-Responsive Controlled Release System by Covalent Immobilization of Proteins Into Mesoporous Silica Nanoparticles
Kai H. Griebenow, University of Puerto Rico, Rio Piedras

408b

Engineering and Characterizing Aggregation-Resistant Antibodies
Joseph M. Perchiacca, Rensselaer Polytechnic Institute; Shantanu V. Sule, Rensselaer Polytechnic Institute; Ali Reza A. Ladiwala, Rensselaer Polytechnic Institute; Jayapriya Jayaraman, Rensselaer Polytechnic Institute; Moumita Bhattacharya, Rensselaer Polytechnic Institute; Peter M. Tessier, Rensselaer Polytechnic Institute

408c

Characterization of Monoclonal Antibody Conformations and Self-Associations At High Concentrations Using Neutron Scattering Techniques
Yun Liu, NIST; Eric J. Yearley, University of Delaware; Isidro Zarraga, Genentech Inc.; Norman J. Wagner, University of Delaware; Thomas M. Scherer, Genentech Inc.; Steven J. Shire, Genentech Inc.; Yatin R. Gokarn, Genentech Inc.

Break

408d

Aggregation of Proteins Studied by Deep UV Resonance and Nonresonance Raman Spectroscopy
Sergey Arzhantsev, US FDA; Connie Ruzicka, US FDA; Vincent Vilker, FDA; John Kauffman, US FDA

408e

Reactivity of Polymersome Encapsulated Hemoglobin with Physiologically Important Gaseous Ligands: Oxygen, Carbon Monoxide, and Nitric Oxide
Shahid Rameez, The Ohio State University; Uddyalok Banerjee, The Ohio State University; Jorge Fontes, The Ohio State University; Alexander Roth, The Ohio State University; Andre Palmer, The Ohio State University

408f

Low-Viscosity Highly Concentrated Dispersions of Stable Protein Nanoclusters for Subcutaneous Injection
Aileen K. Dinin, University of Texas at Austin; Ameya U. Borwankar, University of Texas at Austin; Maria Andrea Miller, University of Texas at Austin; Tarik A. Khan, The University of Texas at Austin; Brian Wilson, University of Texas at Austin; Kevin Kaczorowski, Massachusetts Institute of Technology; Jennifer A. Maynard, University of Minnesota; Thomas M. Truskett, The University of Texas at Austin; Keith P. Johnston, The University of Texas

See more of this Group/Topical: Topical 7: Biomedical Applications of Chemical Engineering

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