Multi-Scale in Vivo Systems Analysis of Cell-Cell Communication and Signaling in Complex Disease

Complex diseases such as cancer, arthritis, diabetes, and endometriosis involve interactions of tissue cells with immune system cells via molecular communication processes, and resulting disease consequently arises from dysregulated signaling network activities governing pathological cell behaviors.  We are employing combined experimental/computational systems biology approaches to understand these communication and signaling processes at multiple scales, integrating across multiple intracellular pathways, multiple extracellular factors, and multiple cell types, with emphasis on in vivo studies in animal models and human subjects.  This talk will present an overview of our paradigmatic concept, technical approaches, and example applications.