Habit Modification Efforts to Improve Particle Properties of a Pfizer Drug Candidate

HABIT MODIFICATION EFFORTS TO IMPROVE PARTICLE PROPERTIES OF A PFIZER DRUG CANDIDATE

Anil M. Rane* Kevin Girard

Pfizer Global Research & Development, Groton CT 06340

Designing a process that delivers API with desired particle attributes (particles size and shape, bulk powder properties, etc.) directly out of the crystallization makes the drug product formulation process more robust and less expensive.  Habit modification is one of the particle engineering tools we used to alter crystal morphology (aspect ratio) of a Pfizer drug molecule that resulted in improved physical properties (bulk density, FFC etc).  This work will present our habit modification efforts leading to improved particle properties.