Pharmaceutical co-crystals were assembled directly via chemical synthesis by cooling under three new strategies. The screening method for direct co-crystal assembly by a chemical reaction was developed based on liquid-assisted grinding. The ternary phase diagram including a chemical reaction and co-crystallization was established for a 2 : 1 co-crystal of benzoic acid–sodium benzoate.
See more of this Session: Process Intensification and Advanced Control of Pharmaceutical Processes
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum