Multiphysics Modeling of Microfluidic Device to Investigate the Effect of Electric Field on Drug Delivery into the Tumor Cell

Studying the uptake rate of the macromolecules under the effect of electrokinetics phenomena (electrophoresis, electroporation, and electroosmosis) has an application in personalizing electrochemotherapy treatment. The uptake rate of chemotherapeutics can be a marker for single cell characterization. In this study, the COMSOL Multiphysics simulation to solve equation-based computational model on coupled electroporation and mass transfer theories is presented. The outcome of the improved mathematical model can predict the outcome of electrochemotherapy based on the drug physical properties. The design of current microfluidic devices can be optimize for the consideration of the electroosmosis effect on drug uptake rate. We have simulated the novel microfluidic device to study the effect of simultaneous electrokinetics phenomena on cell lysis and uptake rate of the macromolecules by the COMSOL Multiphysics simulation.