344 Continuous Processing Technologies Applied in Drug Product Manufacturing


Description:
Enabled by new technology, continuous processing offers new methods of increasing safety, selectivity, quality, consistency, agility and yield for chemical and biochemical processes. Improved control over process streams enables operation at optimum conditions with reduced sensitivity to scale-up effects. This session will focus on applications of continuous processing to the production of drug substances and products or their intermediates. The session is keen to attract papers which provide an insight to continuous processing state of the art and its association to industrial application in the manufacturing environment.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B), Next-Gen Manufacturing (T6A)


Chair:
Mark Barrett
APC Ltd
Dublin 4
4
Email: mark.barrett@approcess.com

Co-Chair:
Joe Hannon
DynoChem Inc
Wilmington, DE
19803
Email: joe.hannon@scale-up.com


Papers:
344a
Assessing the Adequacy of a Sampling Frequency in the Application of PAT to a Continuous Manufacturing Process for Drug Product
Salvador García-Muñoz, Eli Lilly and Company; Lukas Barnes, Eli Lilly & Co.; Evan Hetrick, Eli Lilly and Company; Ian Leavesley, Eli Lilly & Co.; Zhenqi Shi, Eli Lilly & Co.
344b
Continuous Production Technology for Pharmaceutical Semi-Solid and Liquid Formulations: Processability and Influence of Process Parameters on the Product Quality
Nils Bostijn, Ugent; Thomas De Beer, Ghent University; Willem Dhondt, Janssen Pharmaceutica; Jeroen Van Renterghem, Ghent University; Chris Vervaet, Ghent University
344c
Modeling of Residence Time Distribution of a Continuous Dry Granulation Tableting Line
Michael C. Martinetz, Research Center Pharmaceutical Engineering GmbH; Anssi-Pekka Karttunen, University of Eastern Finland; Stephan Sacher, Research Center Pharmaceutical Engineering GmbH; Patrick R. Wahl, Research Center Pharmaceutical Engineering GmbH; Ossi Korhonen, University of Eastern Finland; Johannes G. Khinast, Research Center Pharmaceutical Engineering GmbH
344d
Robust State Estimation of Feeder and Blender Systems in Continuous Pharmaceutical Manufacturing Systems
Jianfeng Liu, Purdue University; Qinglin Su, Purdue University; Mariana Moreno, Purdue University; Carl Laird, Purdue University; Zoltan K. Nagy, Purdue University; Gintaras V. Reklaitis, Purdue University
344e
Large-Scale Experimental Comparison of Batch and Continuous Technologies for Pharmaceutical Tablet Manufacturing
Kensaku Matsunami, The University of Tokyo; Takuya Nagato, Powrex Corporation; Koji Hasegawa, Powrex Corporation; Masahiko Hirao, The University of Tokyo; Hirokazu Sugiyama, The University of Tokyo
344f
A Cost-Benefit Analysis of Continuous Manufacturing Using Discrete Event Simulation
Anne Purdy, Merck & Co. Inc.; Amy Greer, MOSIMTEC LLC; Palmerly Tom, MSD, Ltd.; Ondrej Slama, MSD; Pavlo Minayev, MSD; Vaclav Belak, MSD
344g
Real-Time Monitoring and Control of API Concentration in a Tablet Press for Continuous Manufacturing of Tablets
Jin Maeda, Daiichi Sankyo; M. Sebastian Escotet-Espinoza, Rutgers, The State University of New Jersey; Ravendra Singh, Rutgers, The State University of New Jersey; Marianthi Ierapetritou, Rutgers, The State University of New Jersey
Abstract Submissions Closed
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum
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