142 Emerging Tools and Enabling Technologies in Synthetic Biology


Description:
Synthetic biology applies engineering principles to construct biological systems with unique and useful properties. The process of design and construction of these systems poses major challenges, owing to the complexity of biology. However, emerging tools have enabled the rapid construction of increasingly complex systems with predictable behaviors. This session will cover the development and application of these tools to the diverse topics of synthetic biology. Topics include, but are not limited to, DNA assembly, genetic circuit design and validation, modeling approaches, biomolecular breadboarding, synthetic regulation, cell-cell communication, RNA-based control schemes, and general understanding of biology that stems from design and construction of synthetic systems. Systems will span from in vitro experiments, viruses, and diverse bacteria to eukaryotes (yeast, mammalian cells, and plants). This session will focus particularly on the development of synthetic biology technology and approaches.

Sponsor:
Bioengineering


Chair:
Anushree Chatterjee
Assistant Professor
University of Colorado Boulder
Chemical and Biological Engineering
Boulder, CO
80303
Email: chatterjee@colorado.edu

Co-chairs:
Yongku Cho
Assistant Professor
University of Connecticut
Chemical and Biomolecular Engineering
Storrs, CT
Email: cho@engr.uconn.edu

Kang Wu
Assistant Professor
University of New Hampshire
Chemical Engineering
Durham, NH
Email: kang.wu@unh.edu

Cong T. Trinh
Assistant Professor
University of Tennessee
Department of Chemical and Biomolecular Engineering
Knoxville, TN 37996
Knoxville, TN
37996
Email: ctrinh@utk.edu


Papers:
Using Synthetic Biology to Engineer Epistasis to Deter Bacterial Adaptation
Peter Otoupal, University of Colorado Boulder; Anushree Chatterjee, University of Colorado Boulder
Programmable Control of CRISPR-CAS9 Systems By Engineering Sgrna As Toehold-Switchable Riboregulators
Kay Siu, University of Delaware; Wilfred Chen, University of Delaware
Engineering Post-Translational Proofreading to Discriminate Non-Standard Amino Acids
Aditya M. Kunjapur, Harvard Medical School; Devon Stork, Harvard Medical School; Erkin Kuru, Harvard Medical School; Matthieu Landon, Harvard University; Oscar Vargas-Rodriguez, Yale University; Dieter Söll, Yale University; George M. Church, Harvard University
Developing Robust, Environmentally-Responsive Genetic Circuits for Real-World Applications
Tatenda Shopera, Washington University in St. Louis; Allison Hoynes-O'Connor, Washington University in St. Louis; Young Je Lee, Washington University in St. Louis; Austin Rottinghaus, Washington University in St. Louis; Tae Seok Moon, Washington University in St. Louis
RNA-Aptamer-in-Droplet (RAPID) High-Throughput Screening for Secretory Phenotypes
James M. Wagner, The University of Texas at Austin; Joseph Abatemarco, The University of Texas at Austin; Maen Sarhan, UCSF; Jyun-Liang Lin, The University of Texas at Austin; Leqian Liu, UCSF; Shuo-Fu Yuan, The University of Texas at Austin; Adam R. Abate, UCSF; Hal Alper, The University of Texas at Austin
Enabling Microbial Cell Factories: Synthetic Biology Tools for Efficient Pathway Assembly and Integration
Ee Lui Ang, Agency for Science, Technology and Research; Jing Liang, Agency for Science, Technology and Research; Zihe Liu, Agency for Science, Technology and Research; Shuobo Shi, Agency for Science, Technology and Research; Youyun Liang, Agency for Science, Technology and Research; Mingzi M. Zhang, Agency for Science, Technology and Research; Xi Zhi Low, NUS High School; Huimin Zhao, University of Illinois at Urbana-Champaign
Biology By Design: Emerging Tools in Cell-Free Synthetic Biology
Michael C. Jewett, Northwestern University
Abstract Submissions Closed
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division