Victor Koppejan, Bioprocess Engineering, TU Delft, Delft, Netherlands, Guilherme Ferreria, DSM Biotechnology Center, Delft, Netherlands, Haibin Wang, Zhejiang Hisun Pharmaceutical CO., LTD, Taizhou, China, Dong-Qiang Lin, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China and Marcel Ottens, Biotechnology, Delft University of Technology, Delft, Netherlands