353 Nucleic Acid Materials and Delivery


Description:
This session will cover novel design principles that govern biomaterial design and evaluation for nucleic delivery applications with particular focus on how biomaterial properties (e.g. mechanical properties, chemical composition, degradation kinetics, micro/nano-structure, etc.) influence the delivery efficiency. Possible topics include, but are not limited to design of novel vehicles for nucleic acid delivery, stimuli-sensitive or targeted delivery, enhancement of delivery/transfection efficiency via specific biomaterial properties and the influence of biomaterial properties on intracellular trafficking and/or transport of nucleic acids. Graduate Students: By applying to this session you may be eligible for the Biomaterials Graduate Student Award Session established to honor the best graduate student submissions through recognition and cash awards. See the session titled 'Biomaterials: Graduate Student Award Session' for details.

Sponsor:
Biomaterials
Co-Sponsor(s):
Engineering Fundamentals in Life Science (15D), Bionanotechnology (22B)


Co-chairs:
Forrest Kievit
Assistant Professor
University of Nebraska
Biological Systems Engineering
Lincoln, NE
Phone Number: 402-472-2175
Email: fkievit2@unl.edu

Lorraine Leon
Assistant Professor
University of Central Florida
Materials Science & Engineering
Orlando, FL
60637
Phone Number: 407-823-5378
Email: lorraine.leon@ucf.edu


Papers:
Novel, Stimuli-Responsive Hydrogels Utilizing Ionic Interactions for the Controlled and Targeted Delivery of Nucleic Acid Nanospheres to Prevent Secondary Cataracts
Mark E. Byrne, Rowan University; Laura L. Osorno, Rowan University; Robert Getts, Genisphere, LLC; Mindy George-Weinstein, Philadelphia College of Osteopathic Medicine
miR233-Loaded Immunomodulatory Adhesives for the Treatment of Chronic Wounds
Bahram Saleh, Northeastern University; Harkiran Dhaliwal, Northeastern University; Roberto Portillo Lara, Northeastern University; Ehsan Shirzaei Sani, Northeastern University; Mansoor Amiji, Northeastern University; Nasim Annabi, Massachusetts Institute of Technology
Lipid Nanoparticle- Mediated Delivery of Chemically Modified mRNA Significantly Enhances Protein Expression in Mice
Khalid A. Hajj, Carnegie Mellon University; Kathryn A. Whitehead, Carnegie Mellon University
Effect of Polyplex Charge on Cellular Internalization and Gene Expression
Landon A. Mott, University of Kentucky; Caleb Akers, University of Kentucky; Daniel W. Pack, University of Kentucky
Characterization of Daunomycin Binding Affinity Toward Specifically Engineered DNA Sequences to Modulate Behavior of Nanoscale Drug Delivery Vehicles
Robert Mosley, Rowan University; Ricky J. Whitener, Auburn University; Jacek Wower, Auburn University; Mark E. Byrne, Rowan University
Dynamic, Reversible Control of Hydrogel Stiffness Using DNA Crosslinkers
Nicholas Stephanopoulos, Arizona State University
Physically Crosslinked DNA-Based Injectable Hydrogels for Bone Regeneration
Sayantani Basu, University of Kansas; Settimio Pacelli, The University of Kansas; Arghya Paul, The University of Kansas
Abstract Submissions Closed
See more of this Group/Topical: Materials Engineering and Sciences Division