Session: Poster Session: Pharmaceutical (2018 AIChE Annual Meeting)

Description:

This poster session highlight academic and industrial research related to advancements in drug discovery, development, and manufacturing. Topics related to drug substance, drug product, and biopharmaceuticals are welcomed.

Sponsor:

Pharmaceutical Discovery, Development and Manufacturing Forum

Co-Sponsor(s):

Pharmaceuticals (15B), Poster Sessions (POSTERSESSIONS)

Chair:

Jonathan McMullen
Associate Principal Scientist, Chemical Engineering Technology Labs
Merck & Co., Inc.
Chemical Engineering Research and Development
P.O. Box 2000
Rahway, NJ
07065
Email: jonathan.mcmullen@merck.com

Co-Chair:

Christopher H. Marton
Principal Engineer
Celgene

Email: cmarton@celgene.com

Papers:

200a

Multi-Scale Modeling in Immuno-Oncology to Support Immunotherapy Drug Development
Mohammad Ghasemi, University at Buffalo - The State University of New York (SUNY); Donald E. Mager, University at Buffalo - The State University of New York (SUNY)

200b

Evaluation of Microfluidic Device Designs for a Potassium Release Toxicity Assay
Joseph Wakim, University of Massachusetts Lowell; Nese Orbey, University of Massachusetts Lowell; Carol Barry, University of Massachusetts Lowell

200c

Effects of Unsaturated Phospholipid Dilinoleoylphosphatidylcholine on Degradation of Phospholipid Vesicles Catalyzed By a Model Phospholipase A2
Pin Zhang, University of Illinois at Chicago; Veronica Villanueva, University of Illinois at Chicago; Joseph Kalkowski, University of Illinois at Chicago; Chang Liu, University of Illinois at Chicago; Tiep Hoang Pham, University of Illinois at Chicago; Wei Bu, University of Chicago; Binhua Lin, Advanced Photon Source / University of Chicago; Ying Liu, University of Illinois at Chicago

200d

Peptoid JPT1A Reduces RAGE Expression and Attenuates Inflammatory Response: A Potential AD Therapeutic
Lauren M. Wolf, University of South Carolina; Melissa A. Moss, University of South Carolina; Shannon L. Servoss, University of Arkansas

200e

Rapid and Efficient Development of Downstream Bio-Pharmaceutical Processing Alternatives
Giorgio Colombo, Politecnico di Milano; Isuru A. Udugama, Technical Univeristy of Denmark; Krist V. Gernaey, Technical University of Denmark; Seyed Soheil Mansouri, Technical University of Denmark

200f

Pump-Down the Mycobacterium Tuberculosis: A DNA Gyrase/P-Glycoprotein Combined Inhibition Approach
Erik Laurini, University of Trieste; Suzana Aulic, University of Trieste; Domenico Marson, University of Trieste; Maurizio Fermeglia, University of Trieste; Irene Briguglio, University of Sassari; Roberta Ibba, University of Sassari; Antonio Carta, University of Sassari; Sabrina Pricl, University of Trieste

200g

Continuous Processing of Doxorubicin-Loaded Liposomes
Antonio Costa, UConn; Raj Mukherjee, UConn; Anand Gupta, UConn; Gowtham Yenduri, UConn; Xiaoming Xu, Office of Testing and Research, U.S. Food and Drug Administration; Celia N. Cruz, U.S. Food and Drug Administration; Bodhisattwa Chaudhuri, University of Connecticut; Diane Burgess, UConn

200h

Experiments and Multi-Scale Models to Understand Liposome Processing Using a Turbulent Jet in Co-Flow
Raj Mukherjee, UConn; Antonio Costa, UConn; Anand Gupta, UConn; Gowtham Yenduri, UConn; Xiaoming Xu, Office of Testing and Research, U.S. Food and Drug Administration; Celia N. Cruz, U.S. Food and Drug Administration; Bodhisattwa Chaudhuri, University of Connecticut; Diane Burgess, UConn

200i

Continuous Protein Crystallization of Lysozyme
Huaiyu Yang, Imperial College London; Wenqian Chen, Imperial College London; Xiaoyu Li, Imperial College London; Peter Peczulis, Imperial College London; Pavan Inguva, Imperial College London; Jerry Y.Y. Heng, Imperial College London

200j

Development of a Unit Operation for Robust Impurity Clearance and Improved Drug Product Stability of a Monoclonal Antibody
Justin Miller, Merck & Co.; Rebecca A. Chmielowski, Merck & Co.; Clark Seth, Merck & Co.; Hong Li, Merck & Co.

200k

Production of Anti-CD20 Monoclonal Antibody Biosimilar
Jianfa Ou, The University of Alabama at Birmingham; Yingnan Si, The University of Alabama at Birmingham; Ningning Xu, The University of Alabama at Birmingham; Daniel D. Flanigan, The University of Alabama at Birmingham; Jiajia Song, The University of Alabama at Birmingham; Lufang Zhou, The University of Alabama at Birmingham; X. Margaret Liu, The University of Alabama at Birmingham

200l

Multi-Stage and Multi-Objective Design Tool for Process Design in Sterile Filling of Biopharmaceuticals
Haruku Shirahata, The University of Tokyo; Philipp Zürcher, Swiss Federal Institute of Technology, Zurich (ETHZ); Sara Badr, The University of Tokyo; Hirokazu Sugiyama, The University of Tokyo

200m

Comparison of Batch and Continuous Biopharmaceutical Antibody Production Based on Techno-Economic Analysis
Ou Yang, Rutgers, The State University of New Jersey; Marianthi Ierapetritou, Rutgers, The State University of New Jersey

200n

Increasing Capacity and Lifetime of Reverse Phase Resin
William McKechnie, Merck and Co., Inc.; Sunitha Kandula, Merck; Nihal Tugcu, Merck

200o

Liquid Phase Synthesis of Monodisperse PEGs By Nanostar Sieving
Danilo Cuccato, Imperial College London; Piers Gaffney, Imperial College London; Ruiyi Liu, Imperial College London; Marc Schaepertoens, Imperial College London; Andrew G. Livingston, Imperial College London

200p

Virtual Screening of Process Parameters for Pharmaceutical Drying Operation: A Combined Doe-CFD Approach
Deepak Jain, Zoetis, Inc.; Joydeep Kant, Zoetis, Inc.; Vishwanath Dalvi, Institute of Chemical Technology; Channamallikarjun Mathpati, Institute of Chemical Technology

200q

Directed Cp*Rh(III)-Catalyzed Fluorosulfonylvinylation of Arenes
Gqwetha Ncube, University of Michigan; Malcolm P. Huestis, Genentech, Inc.

200r

Target-Based Drug Discovery Using Big Data Analytics and Computational Chemistry
J. Jay Liu, Pukyong National University; Petar Zuvela, National University of Singapore

200s

Stoichiometry Identification in Pharmaceutical Reactions Using Dynamic Response Surface Methodology and Target Factor Analysis
Yachao Dong, Tufts University; Christos Georgakis, Tufts University; Jacob Santos-Marques, Tufts University; Jason Mustakis, Pfizer Inc.; Ke Wang, Pfizer Inc.; Jonathan P. McMullen, Merck & Co. Inc.; Shane T. Grosser, Merck & Co., Inc.

200t

Heat Transfer Transients in Semi-Batch Systems: A Computational Approach to Process Intensification and Mitigating Process Hazards
Deepak Jain, Zoetis, Inc.; Joydeep Kant, Zoetis, Inc.; Vishwanath Dalvi, Institute of Chemical Technology; Channamallikarjun Mathpati, Institute of Chemical Technology

200u

Plasmonic Nanocatalysts for Continuous Synthesis of Drug Substances: An Example of Visible-Light Mediated Cross Coupling Reactions
Ravi Teja, oklahoma state university; Andishaeh Dadgar, Oklahoma State University; Farshid Mohammadparast, Oklahoma state University; Marimuthu Andiappan, Oklahoma State University

200v

Flow Chemistry: Continuous Synthesis in Oscillatory Flow Reactor
Zhongyi Yan, Fuzhou University; Huidong Zheng, Fuzhou University

200w

Development and Scale-up of a Robust Impinging Jet Process Under GMP Conditions
Anuj A. Verma, AbbVie Inc.; Kushal Sinha, AbbVie Inc.; Shashank Shekhar, AbbVie

200x

Single-Step Continuous Purification from Liquid-Liquid-Solid Mixture: Design and Experimental Implementation for an HIV Drug Intermediate
Mo Jiang, Virginia Commonwealth University; Boxuan Li, Virginia Commonwealth University; Amos E. Lu, Massachusetts Institute of Technology; Thomas D. Roper, Virginia Commonwealth University; Frank Gupton, Virginia Commonwealth University; Richard Braatz, Massachusetts Institute of Technology

200y

Manipulation of Crystal Morphology of Zoxamide Based on Phase Diagram and Crystal Structure Analysis
Hao Wu, Tianjin University; Shuyi Zong, Tianjin University; Qi Liu, Tianjin University; Jingkang Wang, National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University; Hongxun Hao, Tianjin University

200z

Crystallization Kinetic Measurement and Parameter Estimation Utilizing Population Balance Model in a Dynamic/Oscillatory Baffle Crystallizer
Claire Yiqing Liu, Purdue University; Ayse Eren, Purdue University; Paul Firth, Alconbury Weston Ltd; Alastair Barton, Alconbury Weston Ltd; Jonathon Speed, Keit Spectrometers; Dan Wood, Keit Spectrometers; Zoltan K. Nagy, Purdue University

200aa

Nucleation Kinetics of Pharmaceutical Co-Crystals
Hannah McTague, University of Limerick

200ab

Extrudability Analysis of Drug Loaded Pastes for 3D Printing of Modified Release Tablets
Alaadin Alayoubi, FDA; Ahmed Zidan, FDA; James Coburn, FDA; Bahaa Ghammraoui, FDA; Celia N. Cruz, U.S. Food and Drug Administration; Muhammad Ashraf, Office of Testing and Research, U.S. Food and Drug Administration

200ac

One Step Purification of Curcumin from Its Lower Grades Via Particle Mediated Crystallization
Vasanth Kumar Kannuchamy, University of Limerick; Kirankumar Ramisetty, University of Limerick; Rama Krishna Gamidi, University of Limerick; Claire Heffernan, University of Limerick; Renuka Devi Krishnaraj, Synthesis & Solid State Pharmaceutical Centre, University of Limerick; B. Kieran Hodnett, University of Limerick; Ake Rasmuson, University of Limerick

200ad

Ternary Phase Diagram and Population Balace Model for Solvent-Mediated Phase Transformation of Lansoprazole
Shuyi Zong, Tianjin University; Hongxun Hao, Tianjin University; Jingkang Wang, National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University; Hao Wu, Tianjin University; Qi Liu, Tianjin University

200ae

Advancing Smart Manufacturing in Pharmaceutical Systems
Sudarshan Ganesh, Purdue University; Mariana Moreno, Purdue University; Qinglin Su, Purdue University; Francesco Rossi, Purdue University; Marcial Gonzalez, Purdue University; Zoltan K. Nagy, Purdue University; G. V. Rex Reklaitis, Purdue University

200af

Dropwise Manufacturing of Oral Solid Dosage Forms Using Powder Slurries
Andrew J. Radcliffe, Purdue University; Zoltan K. Nagy, Purdue University; Gintaras V. Reklaitis, Purdue University

200ag

Effect of Process Parameters on Stability of Lactate Dehydrogenase during Bulk Freeze-Thaw
Bruna Minatovicz, University of Connecticut; Li Sun, Regeneron Pharmaceuticals; Robin Bogner, University of Connecticut; Bodhisattwa Chaudhuri, University of Connecticut

200ah

Effect of Solvent in Strip Film Manufacturing Containing BCS CLASS II Drugs VIA Solution Casting
Eylul Cetindag, New Jersey Institute of Technology; John Pentangelo, New Jersey Institute of Technology; Rajesh Davé, New Jersey Institute of Technology

200ai

Droplet-Coalescence Kinetics for a Non-Newtonian Emulsion Using a Taylor-Couette Shear-Flow Reactor: Characterizing Phase-Separation Risk for a Pharmaceutical Ointment
Arya Ketabchi-Haghighat, Iowa State University; R. Dennis Vigil, Iowa State University; Michael Olsen, Iowa State University; Avik Sarkar, Worldwide Research and Development, Pfizer Inc.

200aj

Unique Polymorph and Amorphous Dispersion Formation of Suberic Acid Using Monodisperse Droplet Evaporation
Victoria Karakis, Bucknell University; Erin Ditmar, Bucknell University; Kurt R. Vostal, Bucknell University; Ryan C. Snyder, Bucknell University

200ak

Importance of the Reaction Kinetics of Drug-Bile Micelle Formation in Oral-Drug Absorption Modeling
Brian Shoemaker, Pfizer Inc.; Fady Ibrahim, Pfizer Inc.; Ravi M. Shanker, Pfizer Inc.; Avik Sarkar, Worldwide Research and Development, Pfizer Inc.

200al

Anti-Static Agent Addition in Excipients – Always a Decent Way to Increase Powder Process-Ability in Pharmaceutical Industries?
Quentin Ribeyre, GranuTools; Simon Bocquet, GranuTools; Filip Francqui, GranuTools; Geoffroy Lumay, University of Liège

Abstract Submissions Closed

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200 Poster Session: Pharmaceutical