15 Automation and High-Throughput Technologies for Pharmaceutical Discovery and Development


Description:
This session will highlight the increasing contribution of machines to accelerating pharmaceutical discovery and development. Innovative uses of miniaturization, automation, high-throughput experimentation, and analytical techniques for enabling of pharmaceutical advances are discussed. Integrated approaches merging experimental and modeling methods with the intent of learning or optimizing through feedback are also discussed. Submissions apply generally to the topic of Innovative Technologies to Accelerate and Enhance Drug Discovery, Development, and Manufacturing.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B)


Chair:
Brandon Reizman
Associate Sr. Consultant Engineer
Eli Lilly and Company
Small Molecule Design and Development
77 Massachusetts Ave
Indianapolis, IN
02139
Phone Number: 3176510812
Email: breizman@lilly.com


Papers:
15a
A New High-Throughput Assay for Quantification of Antibiotic Penetration in Gram-Negative Bacterial Cells
Huan Gu, Syracuse University; Zhaowei Jiang, Syracuse University; Dacheng Ren, Syracuse Biomaterials Institute
15b
Deploying Automation to Execute Real-Time Feed Strategies in Bench-Scale Bioreactor Systems
Kristin O'Neill, Merck & Co., Inc.; William Tran, Merck & Co., Inc.; Linda Hoshan, Merck & Co., Inc.; Sen Xu, Merck & Co., Inc.; T. Craig Seamans, Merck & Co., Inc.
15c
Very Large Scale Microfluidic Droplet Integration for Continuous Industrial Scale Manufacturing of Monodisperse Biodegradable Micro and Nanoparticles
Sagar Yadavali, University of Pennsylvania; Heon Ho Jeong, University of Pennsylvania; Daeyeon Lee, University of Pennsylvania; David Issadore, University of Pennsylvania
15d
Applying Automation and Data-Driven Modeling to Perform Rapid Reaction Optimization
Daniel Griffin, Amgen Inc.; Seth Huggins, Amgen Inc.
15e
Piezoelectric-Based Spray Solvent Delivery System for Desorption Electrospray Ionization Mass Spectrometry: Design & Case Studies for High Throughput Reaction Screening
Botond Szilagyi, Purdue University; Andy Koswara, Purdue University; Bradley P. Loren, Purdue University; Harrison S. Ewan, Purdue University; Christina E. Ferreira, Purdue University; David H. Thompson, Purdue University; Robert G. Cooks, Purdue University; Zoltan K. Nagy, Purdue University
15f
Closed-Loop Reaction Optimization in Microscale Oscillating Droplets: An MINLP Algorithm Applied to Suzuki-Miyaura Coupling Catalyst Selection
Connor W. Coley, Massachusetts Institute of Technology; Lorenz M. Baumgartner, Massachusetts Institute of Technology; Brandon Reizman, Eli Lilly and Company; Kevin W. Gao, University of California, Berkeley; Klavs F. Jensen, Massachusetts Institute of Technology
15g
Reaction Screening in an Automated Droplet Screening System for Pharmaceutical Process Development
Michael Wleklinski, Eli Lilly and Company; Brandon Reizman, Eli Lilly and Company
Abstract Submissions Closed
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