391 Continuous Processing Technologies Applied in Drug Substance Manufacturing II


Description:
Continuous processing in pharmaceutical development and manufacturing has significant advantages in terms of increased safety, throughput, selectivity, and quality compared to batch processing. Research is being carried out extensively in industry and academia for utilizing continuous technology from simple unit operations to multi-step chemical syntheses. This session will focus on applications and advances made by continuous processing relating to the production of drug substances. The session encourages talks elaborating on experimental approaches for scaling up, model predictions to understand the functioning of unit operations, and fundamentals inherent to continuous manufacturing (e.g. residence time distribution).

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B)


Chair:
Shujauddin M. Changi
Sr Consultant Engineer
Eli Lilly and Company
2300 Hayward Street
Indianapolis, IN
48109
Email: smchangi@lilly.com

Co-Chair:
Brian M. Wyvratt
Merck & Co., Inc.
Chemical Engineering R&D
Rahway, NJ
48109
Email: brian.wyvratt@merck.com


Papers:
391a
A Comparative Study of Residence Time Distribution and Cooling Crystallization in a Continuous Dynamic/Oscillatory Baffle Crystallizer Versus a Stirred Tank
Claire Yiqing Liu, Purdue University; Alastair Barton, Alconbury Weston Ltd; Paul Firth, Alconbury Weston Ltd; Jonathon Speed, Keit Spectrometers; Dan Wood, Keit Spectrometers; Zoltan K. Nagy, Purdue University
391b
Design of Fluoropolymer Membrane Systems for the Dehydration of Organic Solvents for Use in Continuous Flow Chemistry Pharmaceutical Processes
Hannah Murnen, Compact Membrane Systems; Evan Sohodski, Compact Membrane Systems; Sudip Majumdar, Compact Membrane Systems; Bryan Feyock, Compact Membrane Systems
391c
Advanced, Material-Aware Model Predictive Control Strategies for Evaporation Processes in the Pharmaceutical Industries
Ioana Nascu, Texas A&M Energy Institute, Texas A&M University; Nikolaos A. Diangelakis, Texas A&M University; Salvador García-Muñoz, Eli Lilly and Company; Efstratios N. Pistikopoulos, Texas A&M University
391d
Applications of Continuous Isolation and Drying in Pharmaceutical Manufacturing
Christopher S. Polster, Eli Lilly and Company; Alexander M. Heller, Eli Lilly and Co
391e
Development of a Novel Drying Technology for Drying of Wet API’s
Manuel Zettl, Research Center Pharmaceutical Engineering; Manuel Kreimer, Research Center Pharmaceutical Engineering; Isabella Aigner, Research Center Pharmaceutical Engineering; Markus Krumme, Novartis Pharma AG; Thomas Mannschott, Novartis Pharma AG; Peter van der Wel, Hosokawa Micron B.V.; Johannes G. Khinast, Research Center Pharmaceutical Engineering
391f
Possibilities and Limitations of Static Mixers in Precipitating Environments
Manuel Zettl, Research Center Pharmaceutical Engineering; Manuel Kreimer, Research Center Pharmaceutical Engineering; Isabella Aigner, Research Center Pharmaceutical Engineering; Markus Krumme, Novartis Pharma AG; Thomas Mannschott, Novartis Pharma AG; Peter van der Wel, Hosokawa Micron B.V.; Johannes G. Khinast, Research Center Pharmaceutical Engineering
391g
Coupling Flow Synthesis and Formulation By Electrospinning
András Domokos, Budapest University of Technology and Economics; Attila Balogh, Budapest University of Technology and Economics; Balázs Farkas, Budapest University of Technology and Economics; Balázs Démuth, Budapest University of Technology and Economics; Hajnalka Pataki, Budapest University of Technology and Economics; Zsombor K. Nagy, Budapest University of Technology and Economics; György Marosi, Budapest University of Technology and Economics
Abstract Submissions Closed
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