252 Advancements in Polymers and Amorphous Solids for Pharmaceutical Process Development


Description:
This session includes papers within the scope of particle engineering and material sciences of active pharmaceutical ingredients and excipients to enable pharmaceutical formulation design and development, specifically centered on polymers and amorphous solids. Abstracts related to novel process designs to achieve product specifications, methods to understand and manipulate particle attributes and scale up of particle engineering are of interest. Advancements in experimental, theoretical, and computational tools to characterize and predict solid properties are considered, as are particle engineering approaches for amorphous drug products.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Particle Technology Forum (03)


Chair:
Blair Kathryn Brettmann
Georgia Institute of Technology
Materials Science and Engineering
Atlanta, GA
60615
Email: blair.brettmann@mse.gatech.edu

Co-chairs:
Pavithra Sundararajan
Merck Sharp & Dohme
West Point, PA
19486
Email: pavithra.sundararajan@merck.com

Steven J. Brenek
Principal Scientist
Pfizer, Inc
Chemical R&D
Eastern Point Road
Groton, CT
06340
Phone Number: 8604411785
Email: steven.j.brenek@pfizer.com


Papers:
252a
Synthetic and Compositional Control of Multicompontent Copolymers to Promote Drug Solubility and Bioavailability
Theresa M. Reineke, University of Minnesota
252b
Nanocellulose Gels As a Flexible, High Surface Area Material for Crystallizing Pharmaceuticals
Blair Kathryn Brettmann, Georgia Institute of Technology
252c
Controlling the Particle Morphology of Spray Dried Poly(methacrylic acid-co-methyl methacrylate) (Eudragit L100) Polymer
Kimberly B. Shepard, Lonza; Michael Morgen, Lonza
252d
Application of Fundamental Relationships and Models to Predict Spray-Dried Dispersion Particle Size
John Baumann, Lonza; Alyssa Ekdahl, Lonza; Chris Craig, Lonza
252e
Improving Spray Drying Processing through Modeling and Characterization
Pavithra Sundararajan, Merck Sharp & Dohme
252f
Mechanistic Approach to Predict Amorphous Solid Dispersion Thermal Degradation in Spray Drying Processes
Gonçalo Poeiras, Instituto Superior Técnico, University of Lisbon; Tiago Porfirio, Hovione; Clara Sá Couto, Hovione; João Pereira, Hovione; Rui C. Silva, Hovione; Íris Duarte, Hovione; Maria Diná Afonso, Instituto Superior Técnico, University of Lisbon; João Vicente, Hovione
252g
Downstream Processing of a Ternary Amorphous Solid Dispersion: The Impacts of Spray Drying and Hot Melt Extrusion on Powder Flow, Compression and Dissolution
Mark Davis, University of Limerick; Catherine Kelly, Bernal Institute, University of Limerick; Gavin Walker, University of Limerick
Abstract Submissions Closed
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum
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