381 Advancements in Particle Engineering for Crystallization in Pharmaceutical Process Development


Description:
This session includes papers within the scope of particle engineering and material sciences of active pharmaceutical ingredients and excipients to enable pharmaceutical formulation design and development, specifically centered on crystallization processes. Abstracts related to novel process designs to achieve product specifications, methods to understand and manipulate particle attributes and scale up of particle engineering are of interest. Advancements in experimental, theoretical, and computational tools to characterize and predict solid properties are considered, as are particle engineering approaches for crystallization.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B)


Chair:
Lei Zhu
Merck & Co.
Rahway, NJ
Email: lei.zhu2@merck.com

Co-Chair:
Samir Kulkarni
Pfizer

Email: samir.kulkarni@pfizer.com


Papers:
381a
Crystal Engineering of Needle Shaped API - a Mechanistic Modelling Approach
Anna Jawor-Baczynska, Astra Zeneca; Leonor Rosa, Process Systems Enterprise; Niall Mitchell, Process Systems Enterprise
381b
Strategies for Crystallization Development of Process Intermediates in Early and Late Stage Manufacturing Processes
David W. Place, Pfizer
381c
Polymorphism Control Via Combined Cooling and Antisolvent Crystallization in Continuous Mixed Suspension Mixed Product Removal Crystallizers
Shivani Kshirsagar, Purdue University; Botond Szilagyi, Purdue University; Zoltan K. Nagy, Purdue University
381d
Anticipate and Avoid Oiling out in Crystallization Using Molecular Dynamics Simulations
Deepak Jain, Zoetis, Inc.; Joydeep Kant, Zoetis, Inc.; Vishwanath Dalvi, Institute of Chemical Technology; Channamallikarjun Mathpati, Institute of Chemical Technology
381e
Controlling Crystal Size Via Fine Particle Dissolution in a Closed Loop Wet Milling Crystallization
Kirankumar Ramisetty, University of Limerick; Ake Rasmuson, University of Limerick; Tom O'Ceallaigh, Merck; Aaron Cote, Merck; Denise Croker, Bernal Institute, University of Limerick
381f
Sonoseeding: An Alternative Approach for Scale-up of Batch Sonocrystallization
Kirankumar Ramisetty, University of Limerick; Vasanth Kumar Kannuchamy, University of Limerick; Ake Rasmuson, University of Limerick
381g
Crystal Form and Morphology Control of Obeticholic Acid By Crystallization in Sected Solvents
Shichao Du, Tianjin University; Yan Wang, Tianjin University; Junbo Gong, Collaborative Innovation Center of Chemical Science and Engineering; Xiaoyue Tan, Nankai University
Abstract Submissions Closed
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