336 Enabling and Advanced Formulations in Drug Product Processing I: Focus on Dissolution


Description:
These sessions highlight research related to drug product processing for solubility enhancement or other advances in the manufacture of challenging oral formulations. Solubility enhancement includes, but is not limited to, processing of amorphous solid dispersions via spray drying or hot melt extrusion. This session focuses on drug release from advanced or enabled formulations.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Particle Technology Forum (03)


Chair:
Brendon G. Ricart
Associate Director
AbbVie
Process Engineering Sciences
WP78-304
North Chicago, IL
19486
Email: brendon.ricart@abbvie.com

Co-Chair:
Kristin J. Ploeger
Merck
77 Massachusetts Ave

02139
Email: kristin_ploeger@merck.com


Papers:
336a
Griseofulvin-Laden Extrudates Prepared Via Nanoextrusion: Impact of Dry-Milling on Dissolution Enhancement
Ecevit Bilgili, New Jersey Institute of Technology; Meng Li, New Jersey Institute of Technology; Casey Furey, New Jersey Institute of Technology; Jeffery Skros, New Jersey Institute of Technology; Rajesh Davé, New Jersey Institute of Technology
336b
­­­­the Effect of Inorganic Salt on Disintegration of Tablets with High Loadings of Kollidon® VA64-Based Amorphous Solid Dispersion
Hanmi Xi, Merck & Co., Inc.; Jie Ren, Merck & Co., Inc.; Julie Novak, Merck & Co., Inc.; Eric Kemp, Merck & Co., Inc.; Greg Johnson, Merck & Co., Inc.; Jerry R. Klinzing, Merck & Co., Inc.; Mary Ann Johnson, Merck & Co., Inc.; Wei Xu, Merck & Co., Inc.
336c
Miniaturized Formulation and Processability Screening for the Rational Design of Ethylene Vinyl Acetate Based Co-Extrudates
Ioannis Koutsamanis, University of Graz; Simone Eder, Research Center Pharmaceutical Engineering GmbH; Stefan Mohr, Research Center Pharmaceutical Engineering GmbH; Karin Eggenreich, Research Center Pharmaceutical Engineering GmbH; Michela Beretta, Research Center Pharmaceutical Engineering GmbH; Amrit Paudel, Research Center Pharmaceutical Engineering GmbH; Klaus Nickisch, Evestra Inc.; Maika Friedrich, Evestra Inc.; Eva Roblegg, University of Graz
336d
Advances in Dissolution Modeling for Oral Dosage Forms with Amorphous Solid Dispersions
Pedro Valente, Hovione FarmaCiência SA; Mafalda Paiva, Hovione FarmaCiência SA; Ricardo Sousa, R&D Drug Product Development; João Henriques, Hovione FarmaCiência SA; Márcio Temtem, Hovione FarmaCiência SA
336e
Modeling the Bead-Dissolution Kinetics for Composite Melt-Spray Congealed (MSC) Multiparticulates
Avik Sarkar, Worldwide Research and Development, Pfizer Inc.; Brian Shoemaker, Pfizer Inc.
336f
Linking Process, Product and Performance By Raman Imaging Analysis
Patrícia Nunes, Universidade NOVA de Lisboa; Mafalda Paiva, Hovione FarmaCiência SA; Pedro Valente, Hovione FarmaCiência SA; Ana Aguiar-Ricardo, Universidade NOVA de Lisboa; Constança Cacela, Hovione FarmaCiência SA; Márcio Temtem, Hovione FarmaCiência SA
336g
Repurposing Pollen Grains for Oral Delivery of Biologics
Pedro Gonzalez-Cruz, Texas Tech University; Shantanu V. Lale, Texas Tech University; Md Jasim Uddin, Texas Tech University; Shashwati Atwe, SutroVxx; Noureddine Abidi, Texas Tech University; Harvinder Singh Gill, Texas Tech University
Abstract Submissions Closed
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum
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