437 Advances in Biocatalysis and Biosynthesis


Description:
This session focuses on the development of new techniques in biocatalysis and biosynthesis of small molecules, including fine chemicals and natural products. Suggested topics include, but are not limited to: (1) Discovery, characterization, and engineering of enzyme reactions and biosynthetic pathways; (2) Rational and combinatorial manipulation of biosynthetic pathways; and (3) Development of activity screening methods and assays. Topics that cover the metabolic engineering of primary metabolites are better suited in the metabolic engineering sections.

Sponsor:
Bioengineering


Chair:
Jason T. Boock
Postdoc
Massachusetts Institute of Technology
Chemical Engineering
120 Olin Hall
Cambridge, MA
14853
Email: boock@mit.edu

Co-Chair:
Nigel Reuel
Assistant Professor
Iowa State University
Chemical and Biological Engineering
Ames, IA
Email: reuel@iastate.edu


Papers:
437a
Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a “Polar Gate” in Stereo-Recognition of Diaryl Ketones
Ye Ni, Jiangnan University; Jieyu Zhou, Jiangnan University; Guochao Xu, Jiangnan University
437b
Discovery of a Pathway for Halogenated, Terminal Alkene, and Terminal Alkyne Amino Acid Biosynthesis
Jorge Marchand, University of California, Berkeley; Michelle C. Chang, University of California, Berkeley
437c
De-Orphanizing the Nocardiosis-Associated Polyketide Synthase
Kai Yuet, Stanford University; James Kuo, Stanford University; Chaitan Khosla, Stanford University
437d
A Transcription Factor Decoy Strategy for Activation of Streptomyces Polyketide and Non-Ribosomal Peptide Gene Clusters
Bin Wang, Institute for Genomic Biology University of Illinois at Urbana-Champaign; Fang Guo, University of Illinois at Urbana-Champaign; Huimin Zhao, University of Illinois at Urbana-Champaign
437e
Yeast Intracellular Staining (yICS): Enabling Rapid Screening of High-Expressing Clones By Directly Quantifying Protein Expression at the Single-Cell Level
Brett Hill, University of Michigan; Syed Rizvi, University of Michigan; Prabhu Ponnandy, University of Michigan; Fei Wen, University of Michigan
437f
Discovery of Novel Genes Regulating Acyl-CoA Availability in Yarrowia lipolytica
Difeng Gao, Clemson University; Michael Spagnuolo, Clemson University; Spencer Smith, Clemson University; Mark Blenner, Clemson University
437g
A Rapid Cell-Free Approach to Production of Enzyme Biocatalysts and Their Encapsulation in Protective Virus-like Particles
Bradley C. Bundy, Brigham Young University; Seung Ook Yang, Brigham Young University
Abstract Submissions Closed
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division
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