499 Bioseparations and Downstream Processing


Description:
This session will focus on highlighting the latest advances in downstream processing relevant to purification/polishing operations including rapid process development, improved efficiency and purity, continuous processing, integration of operations, handling of high titre streams and sustainability issues. Topics to be covered include, but are not limited to: Uni- and multi-modal chromatography, membrane-based separations and filtration, ultracentrifugation, extraction, precipitation and crystallization.

Sponsor:
Bioengineering
Co-Sponsor(s):
Process Research and Innovation (12A), Bio Separations (02G)


Chair:
Zifan Gong
Sr. Scientist
Pfizer Inc.
Pharmaceutical R&D
Chesterfield, MO
Phone Number: 6362470044
Email: zifan.gong@pfizer.com

Co-Chair:
Jiali Du
Scientist II
MedImmune
Washington, D.C., DC
Email: duj@medimmune.com


Papers:
499a
Purification of Exosomes Using Tangential Flow Filtration
Eric Plencner, The Ohio State University; Jeffrey J. Chalmers, The Ohio State University
499b
Model-Based Optimization and Design of Continuous Chromatography for Protein Capture
Ce Shi, Zhejiang University; Zong-Ye Gao, Zhejiang University; Shan-Jing Yao, Zhejiang University; Dong-Qiang Lin, Zhejiang University
499c
Sterile Filtration of Oncolytic Viruses Using Novel Nanoporous Silicon Nitride Membranes
Evan Wright, McMaster University; Shabnam Shoaebargh, McMaster University; Josh Miller, SiMPore Inc.; Jeff Rowan, University of Rochester; Adam Smith, Center for Cancer Therapeutics; Joris Van der Heijden, Center for Cancer Therapeutics; James Roussie, SiMPore Inc.; James McGrath, University of Rochester; David Latulippe, McMaster University
499d
Microscopic Visualization and Analysis of Protein Adsorption and Transport in Ideae- and Deae-Dextran-Modified Capillaries
Aiying Xue, Tianjin University; Yan Sun, Tianjin University
499e
Docking Simulations to Predict Binding Performance of Affinity Ligands for Purification of Butyrylcholinesterase
Rudra Palash Mukherjee, North Carolina State University; Benjamin G. Bobay, Duke University; Geok-Yong Yow, Prometic Bioseparations; Samuel Sarakbi, Prometic Bioseparations; Patrick V. Gurgel, Prometic Bioseparations; Ruben G. Carbonell, North Carolina State University
499f
Computational Design of Peptide Ligands for the Bioseparation of “Fab” Antibody Fragments
Xingqing Xiao, N. C. State University; Hannah Reese, North Carolina State University; Stefano Menegatti, North Carolina State University; Carol Hall, N. C. State University
499g
Downstream Processing in Biomanufacturing: Multimodal Chromatography, Affinity Precipitation and Integrated Bioprocessing
Steven Cramer, RPI
Abstract Submissions Closed
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division
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