447 Cell Biomechanics, Adhesion and Migration I: Implications in Cancer


Description:
This session will focus on experimental and theoretical aspects of prokaryotic and eukaryotic cell biomechanics, adhesion, and migration. Appropriate papers include those addressing fundamental molecular mechanisms of cell-cell and cell-matrix/surface interactions in two or three dimensional structures, as well as the roles of these cellular processes in tissue engineering, cell physiology, or biotechnology. Papers may also include studies of matrix remodeling (proteolysis, contraction, synthesis), matrix-driven phenotype, or tissue architecture regulation of cellular processes, as well as evaluation of critical biomaterial design parameters to control or guide cell behavior.

Sponsor:
Engineering Fundamentals in Life Science


Chair:
Ebong Eno
North Eastern University

Email: e.ebong@neu.edu

Co-Chair:
Esther Gomez
Pennsylvania State University

Email: ewgomez@engr.psu.edu


Papers:
447a
Investigating the Spatiotemporal Dynamics of Paxillin Isoform Switching in Epithelial-Mesenchymal Transition
Michael Reddick, Stanford University; Rajarshi Ghosh, Stanford ChEM-H; Jan Liphardt, Stanford ChEM-H
447b
Breaking Away from the Pack: Lateral Compression Induces Single Cell Dissociation from Collectively Migrating Cancer Cells
Robert Law, Johns Hopkins University; Zhizhan Gu, Hong Kong Baptist University; Bin Sheng Wong, Johns Hopkins University; Nianchao Wang, Johns Hopkins University; Konstantinos Konstantopoulos, Johns Hopkins University
447c
Abnormal Nuclear Morphologies in Cancer: Role of Chromatin Regulators
Andrew Tamashunas, University of Florida; Vincent J. Tocco Jr., University of Florida; James Matthews, University of Florida; Hendrik Luesch, University of Florida; Jonathan Licht, University of Florida; Richard Dickinson, University of Florida; Tanmay Lele, University of Florida
447d
Identification of Nucleolin As a Novel L-Selectin Ligand Expressed on Head and Neck Squamous Carcinoma Cells
Tove M. Goldson, University of Texas Medical Branch; Kevin L. Turner, Ohio University; Yinan Huang, Ohio University; Emily G. Caggiano, Ohio University; Susan M. Fennewald, University of Texas Medical Branch; Andres F. Oberhauser, University of Texas Medical Branch; Vicente A. Resto, University of Texas Medical Branch; Monica M. Burdick, Ohio University
447e
Notch Signaling Inhibition Increases E-Selectin Ligand Activity and Alters Cell Migration of Mesenchymal-like Breast Cancer Cells
Christian A. Showalter, Ohio University; Alexander O. Ostermann, Ohio University; Monica M. Burdick, Ohio University
447f
Endothelial Glycocalyx Degradation in Disturbed Flow Enhances the Attachment of MCF7 Breast Cancer Cells Attachment to the Endothelium
Alina Nersesyan, Northeastern University; Solomon Mensah, Northeastern University; Maeve Enright, Northeastern University; Mark Niedre, Northeastern University; Eno E. Ebong, Northeastern University
447g
Invited Speaker: Mechanisms of Metastatic Cell-Decision Making during Migration on Complex Microenvironments
Cynthia Reinhart-King, Vanderbilt University
Abstract Submissions Closed
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