585 Protein Engineering for Therapeutics


Description:
This session will focus on engineering polypeptides for therapeutic applications. Topics of interest include, but are not limited to, selective cell targeting, imaging, disruption or modification of biological processes that contribute to disease, the identification or use of diagnostically relevant proteins, and the development of novel protein-based therapeutics.

Sponsor:
Bioengineering


Chair:
Yongku Cho
Assistant Professor
University of Connecticut
Chemical and Biomolecular Engineering
Storrs, CT
Email: cho@engr.uconn.edu

Co-Chair:
Robert Pantazes
Assistant Professor
Auburn University
Chemical Engineering
Auburn University, AL
Phone Number: 334-844-4805
Email: rjp0029@auburn.edu


Papers:
585a
Structure-Guided Molecular Engineering of a VEGF Antagonist to Treat Retinal Eye Diseases
Jamie B. Spangler, Johns Hopkins University
585b
Probing the Conformation and Phospho-Specificity of Anti-Tau Antibodies Using Yeast Surface Display
Shiyao Wang, University of Connecticut; Yongku Cho, University of Connecticut
585c
Novel Protein Engineered for the Treatment of Malaria
Patrick McKernan, University of Oklahoma; Roger Harrison, University of Oklahoma
585d
A High-Throughput in Vitrocompartmentalization (IVC) Directed Evolution Platform for Engineering Protease Substrate Specificity
Carl A. Denard, University of Texas at Austin; Zachary Bennett, University of Texas at Austin; Joseph Taft, University of Texas at Austin; Joseph DeSautelle, University of Texas at Austin; Rasha Yaghi, University of Texas at Austin; Brent L. Iverson, Univ. of Texas
585e
Exploiting Reactive Chemical Functionality in Antibodies to Introduce Metalloproteinase-Targeting Functional Groups
Laura B. Quinto, Tufts University; Jessica T. Stieglitz, Tufts University; Gregory I. Berumen, Tufts University; Haixing P. Kehoe, Tufts University; James Van Deventer, Tufts University
585f
Optmaven-2.0: A Fast Protocol for de novo Design of Antibody Variable Region Against Aspecific Antigen Epitope
Ratul Chowdhury, The Pennsylvania State University; Matthew F. Allan, Massachussets Institute of Technology; Costas D. Maranas, The Pennsylvania State Univeristy
585g
Biomolecular Engineering for Non-Invasive Imaging and Control of Cellular Function
Mikhail G. Shapiro, California Institute of Technology
Abstract Submissions Closed
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division
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